Neoplasms of immature B and T Cells

Question 1

B cell Acute lymphoblastic leukemia/ Lymphoma

Answer 1

Cell of Origin: Bone marrow precursor B cell
Genotype: Diverse chromosomal translocation: t(12;21) involving CBFalpha and ETV6
Clinical Features: predominantly children; symptoms relating to marrow replacement and panctopenia: aggressive

Question 2

T-cell acute lymphoblastic leukemia/lymphoma

Answer 2

Precursor T cell often thymic origin
Genotype: NOTCH 1 mutations
Predominantly adolescent males; thymic masses and variable bone marrow involvement; aggressive