2-4-16-Pancreas Histology DSA (Cole) Flashcards Preview

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Flashcards in 2-4-16-Pancreas Histology DSA (Cole) Deck (17):
1

The ___ pancreas forms the head of the pancreas and associates with the common bile duct

Ventral

2

The ___ pancreas forms part of the head, body, and tail

Dorsal

3

By week ___, pancreatic acini develop from the ducts

12

4

Endocrine cells are first observed along the base of the differentiating exocrine acini by weeks ___

12-16

5

Each islet is supplied by afferent arterioles, forming a network of capillaries lined by fenestrated endothelial cells which is known as the ____

Insulinoacinar portal system

6

Where do pancreatic acini receive their blood supply?

From venules leaving the surrounding islets--> this vascular system enables a local action on the exocrine pancreas of hormones produced in the islet

7

This independent arterial system supples the pancreatic acini (exocrine)

Acinar vascular system

8

___ is formed by protein secretory acini with apically located zymogen granules

Exocrine pancreas

9

What are the 2 components of the islets of langerhans?

1) insuloacinar portal system
2) anastomosing cords of endocrine cells

10

___ is the vascular component of the islets of langerhans consisting of an afferent arteriole giving rise to a capillary network lined by fenestrated endothelial cells

Insuloacinar portal system

11

This component of the islets of langerhans consists of alpha, beta, delta, and F cells that each secrete their own hormone: ___

Anastomosing cords of endocrine cells

12

Insulin causes an increase in the uptake of glucose via ___ channels

GLUT-2

13

What are the actions of somatostatin?

Inhibit release of glucagon and insulin in a paracrine manner

Inhibt secretion of HCl by parietal cells, release of gastrin from EEC cells

14

___ inhibits somatostatin secretion and inhibits secretion of pancreatic enzymes and blocks secretion of bile by inhibiting gallbladder contractions. Its function is to conserve digestive enzymes and bile between meals.

Pancreatic polypeptide

15

___ stimulates the release of pancreatic polypeptide

CCK

16

Describe the synthesis and secretion of insulin by B cells of pancreas

Preproinsulin --> Proinsulin --> mature insulin --> closure of ATP-sensitive K-ATPase channel regulates insulin release by enabling Ca influx --> GLUT-2 allows glucose to enter and trigger immediate insulin releae

17

By week ___, 2 outpocketings from endodermal lining of the duodenum develop as ventral and dorsal pancreas, each with its own duct

4