Flashcards in 2-4-16-Pancreas Histology DSA (Cole) Deck (17):
The ___ pancreas forms the head of the pancreas and associates with the common bile duct
The ___ pancreas forms part of the head, body, and tail
By week ___, pancreatic acini develop from the ducts
Endocrine cells are first observed along the base of the differentiating exocrine acini by weeks ___
Each islet is supplied by afferent arterioles, forming a network of capillaries lined by fenestrated endothelial cells which is known as the ____
Insulinoacinar portal system
Where do pancreatic acini receive their blood supply?
From venules leaving the surrounding islets--> this vascular system enables a local action on the exocrine pancreas of hormones produced in the islet
This independent arterial system supples the pancreatic acini (exocrine)
Acinar vascular system
___ is formed by protein secretory acini with apically located zymogen granules
What are the 2 components of the islets of langerhans?
1) insuloacinar portal system
2) anastomosing cords of endocrine cells
___ is the vascular component of the islets of langerhans consisting of an afferent arteriole giving rise to a capillary network lined by fenestrated endothelial cells
Insuloacinar portal system
This component of the islets of langerhans consists of alpha, beta, delta, and F cells that each secrete their own hormone: ___
Anastomosing cords of endocrine cells
Insulin causes an increase in the uptake of glucose via ___ channels
What are the actions of somatostatin?
Inhibit release of glucagon and insulin in a paracrine manner
Inhibt secretion of HCl by parietal cells, release of gastrin from EEC cells
___ inhibits somatostatin secretion and inhibits secretion of pancreatic enzymes and blocks secretion of bile by inhibiting gallbladder contractions. Its function is to conserve digestive enzymes and bile between meals.
___ stimulates the release of pancreatic polypeptide
Describe the synthesis and secretion of insulin by B cells of pancreas
Preproinsulin --> Proinsulin --> mature insulin --> closure of ATP-sensitive K-ATPase channel regulates insulin release by enabling Ca influx --> GLUT-2 allows glucose to enter and trigger immediate insulin releae