2

Question 1

Opioid misuse

Answer 1

Acute OD - IV/IM naloxone

Detox - methadone/buprenorphine - 4 weeks inpatient or 12 weeks outpatient

Question 2

Causes of lung fibrosis

Answer 2

Amiodarone, methotrexate, nitrofurantoin

Question 3

Contraindications of sildenafil (viagra)

Answer 3

Nitrates, nicorandil, hypotension, recent stroke/MI

Question 4

Drugs with zero order kinetics

Answer 4

Phenytoin, salicyclates, heparin, ethanol

Question 5

Drugs affected by acetylator status (being dificient in hepatic N-acetyltransferase)

Answer 5

Isoniazid, procainamide, hydralazine, dapsone, sulphasalazine

Question 6

CYP450 inducers

Answer 6

Phenytoin, carbamazepine, phenobarbtone, rifampicin, St John’s Wort, chronic alcohol intake, griseofulvin, smoking

Question 7

CYP450 inhibitors

Answer 7

Ciprofloxacin, erythromycin, isoniazid, cimetidine, omeprazole, amiodarone, allopurinol, ketoconazole, fluconazole, fluoxetine, sertraline, ritonavir, sodium valproate, acute alcohol intake, quinupristin

Question 8

Clenched jaw and eyes are deviated upwards caused by a medicaiton

Answer 8

Oculogyric crisis
Due to phenothiazines, haloperidol, metoclopramide
Mx - IV antimuscarinic (benztropine/procyclidine)

Question 9

Neuropathic pain

Answer 9

Amitriptyline/pregabalin –> amitriptyline + pregabalin –> tramadol + refer to pain specialist

Question 10

Diabetic neuropathic pain

Answer 10

Duloxetine

Question 11

Heparin

Answer 11

IV, short duration of action, monitored with APTT, activates antithrombin III, can cause hyperkalaemia

Question 12

LMWH

Answer 12

IM, long duration of action, monitored with anti-factor Xa, activates antithrombin III, can cause hyperkalaemia

Question 13

Heparin OD

Answer 13

Protamine sulphate

Question 14

Lithium toxicity can be precipitated by

Answer 14

Dehydration, renal failure, diuretics (bendroflumethiazide), ACE inhibitors, NSAIDs and metronidazole