2. Basics: Adaptive Immunity Flashcards
how long does the adaptive immune response take
1-2 weeks (delayed response)
what is different about the adaptive response vs the innate response
the adaptive response is specific for the pathogen
what is the aim of adaptive immunity
aims to eliminate infection and prevent re-infection later
what is the aim of innate immunity
aims to eliminate infection and alert the immune system
what is the relationship between DCs and T cells
the DC produces signals that instruct the T cell which type to differentiate into
give an example of a signal produced by a dendritic cell and the type of T cell that is produced
DC produces IL-4
type 2 helper T cells
what do type 2 helper T cells do
activate eosinophils
defence against extracellular parasites
what type of cells are CD8 T cells
cytotoxic t lymphocytes (CTLs)
what 4 things do CTLs secrete
perforin
granzymes
IFNgamma
TNFalpha
the 5 immunoglobulin classes: what is the role of this one:
IgM (pentamer)
main antibody of primary responses
the 5 immunoglobulin classes: what is the role of this one:
IgG (monomer)
main blood antibody of secondary responses
- neutralises toxins, opsonisation
the 5 immunoglobulin classes: what is the role of this one:
IgA (dimer)
secreted into mucus, tears, saliva, colostrum
the 5 immunoglobulin classes: what is the role of this one:
IgE (monomer)
antibody of allergy and antiparisitic activity
the 5 immunoglobulin classes: what is the role of this one:
IgD (monomer)
B cell receptor
what 4 things can antibodies do?
neutralise
agglutinate
precipitate soluble antigens
activate the complement system
