2. Dermatology Flashcards Preview

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Flashcards in 2. Dermatology Deck (7)
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Name 6 functions of the skin.

1. Protective barrier against environmental insults, inc. trauma, UV light and pathogens

2. Immunosurveillance

3. Sensation

4. Temperature and fluid regulation

5. VitD synthesis

6. Cosmesis




Name the 4 major cell types of the epidermis and state their function.

1. Keratinocytes - protective barrier

2. Langerhans cells (stratum spinosum) - APCs

3. Melanocytes (stratum basale) - melanin protection to protect nuclei from UV DNA damage

4. Merkel cells - mechanoR cells for sensation 


Describe the 4 layers of the epidermis. Where is an extra layer found?

1. Stratum corneum

2. Stratum granulosum

3. Stratum spinosum

4. Stratum basale - site of keratinocyte mitosis. Cells then move up layers, losing ability to divide.


Stratum lucidum found in areas of thicker skin, e.g. palms and soles.


What is the dermis composed of?

Collagen, elastin and glycosaminoglycans - provides strength and elasticity.


Also contains immune cells, nerve cells, skin appendages. lymphatics and blood vessels. 


What is this condition? Why can it occur and what are the symptoms and consequences?

ERYTHRODERMA = general exfoliative dermatitis with erythema and scaling, involving 90%+ of P's skin


Most commonly caused by exacerbation of underlying skin condition, e.g. psoriasis or eczema, but can also be caused by drug allergy or cutaneous T cell lymphoma.


Symptoms: pruritis, fatigue, anorexia, cold



- hypothermia (loss of thermoregulation)

- infection (loss of protective barrier)

- renal failure (insensible losses)

- cardiac failure (dilated skin vessels)

- protein malnutrition (high skin turnover)