2- Emergency paediatrics (2/2) Flashcards
(69 cards)
Poisoning of unknown origin
- Accidental incidents common in children <6
- Intentional ingestions and recreational drug use in older children and adolescents
–>Mental illness (suicide and attempted self harm) - Think of Munchausen
common poisoning of unknown origin in <6
o Prenatal iron supplements
o Antidepressants
o Cardiotoxic agents
o Illicit drugs
o Analgesics
o Aspirin
common non drug poisoning of unknown origin in
o Hydrocarbons
o Alcohols
o Cleaning products e.g. laundry detergent and bleach)
o pesticides
Presentation POUO
Poisoning of unknown origin should be considered in the differentials of children who present with acute onset of:
- Multiorgan system dysfunction
- Altered mental state
- Resp or cardiac compromise
- Unexplained metabolic acidosis
- Seizures
- Puzzling clinical pictures
Risk factors POUO
- 1-4 yo
- Previous history of ingestion
- Prior history of substance misuse
approach to POUO
Initial evaluation and stabilisation
A to E
Diagnosis of poisoning
- Obtain accurate history
- Location, activity just before injesting
- Risk assessment I.e. suidice and self harm
- Ask paramedics about what they saw e.g. open containers, empty bottles, spilled content
- Toxicology screen
- Clinical response to antedote
Definitive management will depend on substance
Example managements of POUO
- Decontamination using charcoal
- Antidotes
o E.g. naloxone e.g. opioid
o E.g. NAC e.g. paracetamol
o E.g. Flumazenil (diazepam and cocaine)
poisoning antidotes and substrates
Paracetamol overdose (acetaminophen)
Background
- Drug most commonly overdose on are paracetamol, ibuprofen , aspirin, iron, cough medicines and the contraceptive pill
- Children with features of poisoning should be admitted to hospital
- Children who have taken poisons with delayed actions should also be admitted
Pathophysiology of paracetamol overdose
- Toxic doses of paracetamol may cause severe hepatocellular necrosis and much less frequently renal tubular necrosis -> lack of glutathione
- Liver damage is maximal 3-4 days after paracetamol overdose
- Can lead to liver failure, encephalopathy, coma and death
Presentation of paracetamol overdose
- Nausea and vomiting- early features (also recur after 2-3 days)
- Right subcostal pain and tenderness – hepatic necrosis
History for paracetamol overdose
- Dose
- Timing
- Associated ingestions
investigations for paracetamol overdose
Delay sampling to 4h after ingestion
* Paracetamol level.
* U&E – baseline renal status/risk of AKD.
* LFT – monitor ALT levels for hepatotoxicity.
* Glucose – hypoglycaemia common in liver necrosis.
* Clotting screen – INR as PT best indicator of liver necrosis.
* Venous gas –acidosis in 10% of acute liver failure.
Management of paracetamol overdose
Paracetamol Children taking >150mg/kg need assessment
- <1 hour ago give charcoal (prevents absorption) alongside NAC
- N-acetylcysteine: PO or NG loading 140mg/kg, then 70mg/kg/ dose qds for 17 doses.
- IV used if GI bleeding. Repeat blood level at 24hr
N-acetylcysteine MOA
Acts to increase synthesis of glutathione in the liver; which acts as antioxidant and facilitates conjugation of toxins, esp toxic metabolites of acetaminophen.
- Acts to prevent or reduce severity of liver damage
- Can be given up to and possibly beyond 24 hours of ingesting paracetamol
- Most effective if given within 8 hours
paracetamol overdose prognosis
management of aspirin overdose
ACTIVATED CHARCOAL 1G/KG
FLUID REPLACEMENT
URINE ALKALINISATION with sodium bicarbonate
BENZOS FOR SEIZURES (0.1MG/KG)
HAEMODIALYSIS IF SEVERE (ITU)
management of iron overdose
Activated charcoal DOES NOT bind iron
Deferoxamine (DFO)
Metabolic acidosis: 1-2 mmol/kg sodium bicarbonate (1-2 mL/kg 8.4% or 2-4 mL/kg 4.2%) over 20 minutes. Repeat as necessary, aiming for a normal pH.
- administer into a large vein (or via a central line).
Large flush before and after (irritant to vein)
management of benzos overdose
ACTIVATED CHARCOAL 1G/KG (<1H)
FLUMAZENIL
fatal household poisens
CAMPHOR (VICKS / TIGER BALM)
ESSENTIAL OILS
BLEACH
SOLVENTS
WEED KILLER / INSECTICIDES
BUTTON BATTERIES
button batteries
- halo sign on x-ray
- surgical removal
- emergency
- battery acid erodes stomach and can cause catastrophic bleed
mucosal ulceration / necrosis > haemorrhage > perf: FATAL
pneumothorax background
Background
- Occurs in 2% of term infants
- Increased in prematurity and respiratory disease
Presentation of pneumothorax
- Asymptomatic (if small)- most resolve spontaneously
- If large: Respiratory distress
- Tension pneumothorax
-> Respiratory distress
-> Cyanosis
-> Mediastinal shift away from affected side
-> Reduced chest movement and air entry on affected side
-> Transillumination lights up affected side
investigation for pneumothorax
o Ipsilateral translucency
o Lack of peripheral lung markings
o Collapsed lung