2. farmakoloji imminosupresants

Question 1

Calcineurin inhibitörleri hangileridir?

Answer 1

Cyclosporin

Tacrolimus

Question 2

Cyclosporin neye bağlanır?

Answer 2

Cyclophilin

Question 3

Tacrolimus neye bağlanır?

Answer 3

FK-binding protein

Question 4

cyclophilin-Cyclosporin

FK-binding protein*Tacrolimus

Kompleksleri neyi inhibe eder?

Answer 4

Calcineurin

Question 5

Costimulation Blockerlar hangileridir?

Answer 5

Belatacept
Abatacept

Question 6

Belatacept ve Abatacept arasındaki fark nedir?

Answer 6

Belatacept CD80 86 gurubuna daha iyi bağlanır daha güçlüdür

Question 7

Costimulation Blockerlar neyi inhibe eder?

Answer 7

CD80/86 ile CD28 kompleksi oluşumunu engeller

Question 8

MTOR inhibitörleri nelerdir?

Answer 8

Sirolimus
Everolimus

Question 9

imminosupresant Antimetabolitler nelerdir

Answer 9

Azathioprine
Mycophenolate mofetil

Question 10

Azathioprine neye dönüşür?

Answer 10

6-MP

Question 11

Mycophenolate mofetil neyi inhibe eder?

Answer 11

IMPDH

Question 12

İmminosupresant corticosteroidler hangileridir?

Answer 12

Prednisone
Prednisolone
Methyprednisolone

Question 13

İmminosupresant corticosteroidler neye bağlanır?

Answer 13

GR
Gr’de AP-1e ve NF-kBye bağlanır

Question 14

imminosupresant antibodyler hangileridir?

Answer 14

Alemtuzumab
Basiliximab
Rituximab
Antitymocyte globulins

Question 15

signal 1 nedir?

Answer 15

T cell triggering at the CD3 receptor complex
by an antigen presenting cell (APC).

Question 16

Signal 2 nedir?

Answer 16

CD80 86nın CD 28 ile bağlanması

Question 17

sinyal 1 ve iki beraber neyi aktive eder?

Answer 17

interleukin (IL) 2 . diğer adıyla CD25

Question 18

sinyal 3 neyi aktive eder

Answer 18

mTOR

Question 19

Hybridoma technology nedir?

Answer 19

Hybridoma technology
is a method for producing large numbers of identical antibodies

Question 20

Neden Antithymocyte globulin kulanılır?

Answer 20

transplantation to prevent early allograft rejection

Question 21

TUS

Aşağıdaklerden hangisi IL-2 reseptör antikorudur ve bu reseptörün aracılık ettiği T lenfosit Aktivasyonunu engelleyerek immünosupresif etki gösterir?
Deksametazon, talidomit, Metotreksat, siklosporin, daklizumab

Answer 21

daklizumab

Question 22

TUS

Aşağıdakilerden hangisi T-hücresi reseptör kompleksinin antijen tanımasını bloke ederek İmmunosupresyon yapar:
glukokortikoidler,
takrolimus,
muromonab-CD3,
sirolimus

Question 23

Alemtuzumab nereye bağlanır

Answer 23

CD52 on both T and B cells

Question 24

Rituximab nereye bağlanır

Answer 24

CD20 on pre-B cells

Post-Transplant Lymphoproliferative Disease)

Question 25

Muromonab nereye bağlanır?

Answer 25

CD3 on T3

Question 26

Rituximab has a boxed warning for reactivation of?

Answer 26

John Cunningham) virüs leading to progressive multifocal leukoencephalopathy (PML), which has been reported in the nontransplant population Activation of hepatitis B infection has also been reported following treatment, and hepatitis serologies should be monitored.

Question 27

Bortezomib neyi inhibe eder

Answer 27

Bortezomib: proteasome inhibitor

Question 28

Bortezomib hangi hastalıklarda kulanılır?

Answer 28

AMR (Antibody Mediated Rejection)

Question 29

Bortezomib metabolized primarily by?

Answer 29

cytochrome P450 hepatic dysfunction has rarely been reported

Question 30

basiliximab neye bağlanır?

Answer 30

CD25 inhibits IL2

Question 31

Aşağıdaki immünosupresif ajanlardan hangisi kalsineurin bağımlı fosfataz inhibisyonuna neden olur? Glukokortikoid, muromonab-CD3, azotiopürin, takrolismus, mikofenolat mofeti

Answer 31

takrolismus

Question 32

selektif T hücre inhibisyonu yapan ilaç hangisidir Siklofosfamid, siklosporin, kortikosteroid, aktinomisin, bleomisin

Answer 32

siklosporin

Question 33

Spesifik tedavilere cevap alınamayan Behçet üveiti, psöriazis, atopik dermatit, ve romatoid Artrit tedavisinde kullanılan ve nefrotoksik etkisi olan ilaç aşağıdakilerden hangisidir? Paramomisin, metotreksat, siklofosfamid, siklosporin, klorambusil

Answer 33

siklosporin

Question 34

cyclosporine and tacrolimus absorption and metabolism made by ?

Answer 34

CYP3A4, CYP3A5 and P-glycoprotein (P-gp)

Question 35

calcineurin inhibitor kulanımını engelleyen limit nedir?

Answer 35

nephrotoxicity infections

Question 36

cyclosporine'in yan etkileri nelerdir?

Answer 36

Hirsutism, or excessive hair growth,

Question 37

sirolimus and everolimus are metabolized by?

Answer 37

CYP3A4 Sirolimus has a longer half-life

Question 38

Which drug used to prevent allograft rejection can cause hyperlipidemia? A. Basiliximab B. Belatacept C. Mycophenolate mofetil D. Sirolimus

Answer 38

Correct answer = D. Patients who are receiving sirolimus can develop elevated cholesterol and triglyceride levels, which can be controlled by statin therapy. None of the other agents have this adverse effect.

Question 39

Which clinical situation is least appropriate for immunosuppression with sirolimus? A. A patient with primary renal failure. B. A patient who has failed calcineurin inhibitors due to neurotoxicity. C. A patient who is 6 months postliver transplant and the incision site is fully healed. D. A patient with an abnormal lipid profile.

Answer 39

Correct answer = D. A patient with an abnormal lipid profile is a poor candidate for immunosuppression with sirolimus, since this medication is known to cause or exacerbate hyperlipidemia, particularly triglycerides and total cholesterol. A patient with primary renal failure would be a candidate for sirolimus, since it does not cause nephrotoxicity as calcineurin inhibitors do. It would be appropriate to switch a patient who has failed calcineurin inhibitors due to neurotoxicity to sirolimus for immunosuppression since it is not associated with that adverse effect. Sirolimus is known to impair wound healing, but a patient with a fully healed incision site could appropriately be placed on sirolimus.

Question 40

mycophenolate neyi engeller?

Answer 40

guanosine monophosphate oluşumunu B-cell proliferation by eliminating de novo production of guanosine monophosphate.

Question 41

Which immunosuppressant medication avoids the need for therapeutic drug monitoring? A. Cyclosporine B. Tacrolimus C. Mycophenolate mofetil D. Sirolimus

Answer 41

Correct answer = C. Calcineurin inhibitors (cyclosporine and tacrolimus) and mTOR inhibitors (sirolimus and everolimus) require therapeutic drug monitoring in order to maximize efficacy (prevent rejection episodes) and minimize toxicity (adverse effects). Mycophenolate mofetil is the correct answer since there is no role for routine monitoring with this medication.

Question 42

using corticosteroids cause?

Answer 42

cause hypercholesterolemia , cataracts, osteoporosis, and hypertension with prolonged use