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Flashcards in 2 -PT Deck (48):
1

other name for good pastures

anti-glomerular basement membrane disease

2

what is good pastures/anti-glomerular basement membrane disease

auto antibodies against type IV collagen

3

anti-glomerular basement membrane disease/goodpastures, why kidney and pulmonary affected

against type IV collagen that are found in these sites

4

anti-glomerular basement membrane disease/ good pastures: nephritis or nephrotic

nephritis (inflammation = itis)

5

renal biopsy: mesangial proliferation, immunofluorescence+

IgA nephropathy

6

treatment for IgA nephropathy

control BP with ACE, immune suppression

7

Is a systemic variant of IgA nephropathy

Henoch-Schonlein purpura

8

Pathophysiology of Henoch-Schonlein purpura

systemic IgA immune complex formation that causes small vessel vasculitis - get purpuric rash on extensor surfaces, usually legs

9

which types of glomerulonephritis' can cause end stage renal failure

IgA, Henoch-Schonlein purpura

10

good pastures treatment

plasma exchange, steroids +/- cytotoxics (methotrexate)

11

Post strep pathophysiology

strep antigen deposited in glomerulus = immune complex formation and inflammation

12

post strep treatment

supportive

13

immunofluorescence in goodpastiures will show what

IgG

14

4 examples of nephritic

IgA
post strep
vasculitis (wegners)
anti-GBM aka goodpastures

15

In what group of conditions do you see crescenting

nephritic - usually rapidly progressing GN

16

what are those with nephrotic syndrome more prone to infection

urinate out antibodies (IgG)

17

minimal change treatment

steroids - if relapse give cyclophosphamide (chemo)

18

nephrotic syndrome kids get

minimal change

19

diagnosis: immunofluorescence IgM

focal segmental glomerulosclerosis

20

furosemide is what type of diuretic

loop

21

Loop diuretics work how

block NA/K+ pump in ascending loop = no water reuptake = Na, Ca and K+ loss

22

when do you use a loop diuretic (furosemide)

pulmonary and peripheral oedema
hypercalcaemia

23

side effect of loop (furosemide)

hypokalaemia

24

which diuretic can be used to treat severe hypercalcaemia

loop ie: furosemide (get calcium and K+ loss)

25

which type of diuretic cause hypokalemia

thiazide

26

which type of diuretics cause uric aside retention

thiazide

27

how does mantel work

feely filtered but poorly reabsorbed and holds water in tubules via osmotic affect. draws fluid out of tissue into blood.

28

when do you use manetol

in increased intra-ocular and intra caranial pressure

29

diuretic used in glaucoma

acetazolamide

30

acetazolamide is what and used when

diuretic like, causes bicarb and sodium excretion, use din glaucoma to reduce aqueous humour production

31

diuretic that acts on primal tubule

mannitol and actylzolamide

32

diuretic that acts on ascending limb

furosemide

33

diuretic that acts on first part of distal convoluted tubule

thiazide

34

diuretic that acts on end part of dial convoluted tubule

spiranalactone

35

how do you treat hypercalcaemia

treat underlying cause, fluids, IV bisphosphonates

36

streptomycin and gentamicin ar what group of drugs

aminoglycasides - nephrotoxic

37

red/brown urine + high creatinine kinase + high K+

rhabdomyolysis

38

rhabdoyolisis treatment

treat high K+, fluids sodium bicarb to detoxify myoglobin

39

what renal condition can E.coli 0157 cause

haemolytic uraemia syndrome caused by intravascular haemolysis

40

time frame for post strep

usually 3 weeks post infection

41

what is indapamide

thiazide like diuretic

42

hypertension, bradycardia,

cushings reflex = raised intracranial pressure

43

what is polycthemia and why may polycyclic patients get it

excess red blood cell production, excess EPO production. treatment: venesection

44

Diagnosis: kidney disease, hearing loss, eye problems

alport syndrome

45

what is alport syndrome

genetic defect in IV collagen

46

most common type of renal stone

calcium oxalate (primary hyercalcaemia is a risk factor)

47

type of ANCA for wegners diagnosis

c-ANCA

48

most common form of polycyclic kindly disease inheritance

autosomal dominant