2. Solid Tumors Flashcards
1
Q
Define the following prefixes:
* adeno
* carcinoma
* chondro
* fibro
* leio
* lipo
* oma
* osteo
* rhabdo
* sarcoma
A
2
Q
What types of patients do you see ALK rearrangments?
A
younger patients, non smokers, diagnosed with adenocarcinoma
3
Q
Why is it important to find ALK rearengments in NSCLC patients?
A
They respond to FDA apptoved Crizotinib, TKI drug
4
Q
What does ALK rearrengments cause?
A
Activation of ALK kinase which usually activates by extracellular ligand binding
5
Q
What FISH probe is most suitable to detect ALK fusions?
A
ALK dual color break apart probes
