20 - Congenital Heart Dz 2

Question 1

when does ductus arteriosus normally close?

Answer 1

functional closure (via muscle contraction) in 1-2 days
anatomic closure btwn 6 wks and 3 mo

Question 2

consequences of PDA

Answer 2

inc PA bloodflow > LV dilation
inc PA pressure > RV hypertrophy
both of these inc risk for pulm HTN

Question 3

what chemical signal triggers closing of ductus arteriosus after birth?

Answer 3

absence of prostaglandins from placenta

Question 4

what drug can be given to try to stimulate closure of PDA?

Answer 4

indomethacin

Question 5

what drug needs to be given for a ductus arteriosus dependent congenital heart disease?

Answer 5

prostaglandin E (PGE)

Question 6

what other lesions are assoc w/ coarctation of aorta?

a. bicuspid aortic valve
b. congenital and acquired aortic stenosis
c. tubular hypoplasia of arch
d. all of the above

Answer 6

d

Question 7

most common congenital heart abnormality causing death or getting heart transplant in neonate

Answer 7

hypoplastic left heart syndrome

Question 8

current surgical repair of hypoplastic left heart syndrome

Answer 8

basically give whole heart to systemic circulation and connect IVC/SVC directly to pulm arteries

better than what it used to be, but still often causes right heart failure

Question 9

which of the following are ductus dependent lesions?
severe aortic stenosis
pulm valve atresia
VSD
transposition of great arteries
total anomalous pulm venous connection

Answer 9

severe AS
PV atresia
transposition of great arteries