20: Hematopathology Flashcards Preview

Unit 2: Path Pictures > 20: Hematopathology > Flashcards

Flashcards in 20: Hematopathology Deck (58):
1

Peripheral blood smear with many prolymphocytes: small- to medium-sized lymphocytes with clumped nuclear chromatin. Scattered smudge cells (osmotically fragile cells) are also present. What disease?

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B cell SLL/CLL (small lymphocytic lymphoma / chronic lymphocytic lymphoma)

2

Peripheral blood shows smaller RBCs, intense staining and lack of central pallor?

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Hereditary spherocytosis

2

In peripheral blood: anisocytosis (diff sizes), poikilocytosis (teardrop form), nucleated RBCs

In bone marrow: collagen fibrosis, osteosclerosis, abnormal megakaryocytes

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Idiopathic/primary myelofibrosis

3

AML-related neoplastic myeloid cells that have gathered in the skin. 

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Myeloid Sarcoma / Monoblastic Sarcoma / Granulocytic Sarcoma / Chloroma

3

A. Partially effaced lymph node with accumulation of malignant cells in the subcapsular sinus. B. Hallmark cells: large and pleomorphic intrasinusoidal lymphoma cells with kidney-shaped nuclei and an eosinophilic zone near the nucleus. What disease?

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Anaplastic large cell lymphoma (ALCL)

4

What disease presents with hypochromic, microcytic RBCs in peripheral blood; anisopoikilocytosis, target cells, and nucleated red blood cells?

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Thalassemia

5

These lytic bone lesions are associated with what disease?

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Plasma cell myeloma

5

Broad bands of fibrosis in the lymph node against a dense inflammatory background. What Hodgkin subtype?

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Nodular sclerosis Hodgkin lymphoma

5

Reed-Sternberg cells at the arrow, mixed inflammatory background, many small T cells, no fibrotic bands. What Hodgkin subtype?

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Mixed cellularity Hodgkin lymphoma

6

Peripheral smear of what disease?

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Hairy cell leukemia

7

Cells with mirror-image nuclei containing large eosinophilic nucleoli are given what name and are characteristic for what disease?

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Reed-Sternbery cells; Hodgkin's lymphoma

8

Neoplastic follicles with small centrocytes (cleaved cells) and few centroblasts. What grade of follicular lymphoma?

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Grade 1

8

Neoplastic follicle with predominantly centroblasts and few centrocytes. What grade of follicular lymphoma?

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Grade 3

9

What disease presents with lack of central pallor and irregular spikes on RBCs?

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Acanthocytosis

10

Thickened capsule, broad bands of fibrosis, foci of necrosis. What Hodgkin subtype?

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Nodular sclerosis Hodgkin lymphoma

11

These atypical lymphoctyes are characteristic of what EBV presentation?

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Infectious mononucleosis

11

Follicular hyperplasia surrounded by small collections of interfollicular epithelioid macrophages can be seen in what infectious disease?

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Toxoplasmosis

12

Neoplasm showing bone marrow with increased atypical, hypolobated megakaryocytes

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Essential thrombocythemia

12

Bone marrow smear featuring deeply basophilic cytoplasm and lipid vacuoles. What disease?

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Burkitt lymphoma

13

 Kind of anemia in B12 deficiency.

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Megaloblastic anemia / pernicious anemia

(arrows point to megaloblasts, RBC precursors)

14

Anemia where bone marrow consists largely of fat cells and lacks hematopoietic activity.

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Aplastic Anemia

14

Neoplastic follicle with small and large cleaved cells and centroblasts with mutliple nucleoli. What grade of follicular lymphoma?

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Grade 2

15

In this blood smear showing microangiopathic hemolytic anemia due to DIC, what do the curved and straight arrows point to?

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Curved: schistocytes

Straight: Howell-Jolly bodies

15

Lymphoblasts are in the peripheral blood. They have irregular and indented nuclei with fine nuclear chromatin, visible nucleoli, and variable amounts of agranular cytoplasm. What type of blood neoplasm is this?

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Acute lymphoblastic leukemia

15

A stomach biopsy with lymphoepithelial lesions and infiltrating B cells is characteristic of what neoplasm?

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MALT lymphoma

15

Hodgkin/Reed-Sternberg cells in a fibrotic background with reduced reactive lymphocytes. What Hodgkin subtype?

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Lymphocyte-depleted Hodgkin lymphoma

17

Ringed sideroblast (A) and dysplastic megakaryocyte with nuclear separation (B). What disease?

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Myelodysplastic syndrome

18

Neoplastic epithelial cells and normal lymphocytes in what kind of tumor?

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Thymoma

20

PTAH stained glomerulus shows several microthrombi due to what thrombocytopenic condition?

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DIC (disseminated intravascular coagulation)

22

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Hereditary elliptocytosis

23

Hyperplasia of what organ shown here is most commonly associated with myasthenia gravis?

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Thymus

24

Eosinophilic granuloma, shown in this rib section, is a subtype of what kind of neoplasm? (Hint: the electron micrograph shows a Birbeck granule)

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Langerhans cell histiocytosis

25

Neoplastic immune cells can show variable cytologic features ranging from normal-appearing cells (A) to cells resembling blasts (B). Total number, clonality and clinicopathologic findings help distinguish what neoplasm shown?

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Plasma cell myeloma

26

Macrophage engulfing bone marrow cells

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Hemophagocytic syndrome

28

Hypocellular bone marrow, with normal architecture effaced by myeloblasts. What disease?

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AML

30

What kind of cells are seen in this blood smear from a patient with vitamin B12 deficiency?

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Hypersegemented granulocytes

31

APL (subtype of AML). What kind of cytoplasmic inclusions are pointed out by the arrows?

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Auer rods

32

Nucleated RBCs are particularly numerous in what hemolytic disease?

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Hemolytic disease of the newborn 

33

Agglutination caused by what?

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Cold agglutinins / Cold antibody AIHA (autoimmune hemolytic anemia)

35

Dsyplastic, large erythroid precursors in the bone marrow

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Myelodysplastic syndrome

37

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Sickle cell anemia

38

What tumor?

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Thymoma

39

These cerebriform "Sezary cells" are found in the leukemic phase of what neoplasm?

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Mycosis fungoides (cutaneous T-cell lymphoma)

41

Normal lymph node architecture effaced by sheets of mast cells?

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Mastocytosis

43

Schistocytes in a patient with TTP are due to what kind of anemia?

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Microangiopathic hemolytic anemia

44

Lymph node architecture is replaced by a diffuse proliferation of small lymphocytes mixed with larger paraimmunoblasts. What disease?

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B-cell SLL/CLL (small lymphocytic lymphoma / chronic lymphocytic lymphoma)

45

Diffuse proliferation of large lymphoid cells with clonal Ig gene rearrangements. Similar to diffuse large B-cell lymphoma, but occurs in immunocompromised patients. Inset shows EBV+ neoplastic lymphocytes. What disease?

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Posttransplant lymphoproliferative disorders

46

Normal lymph node architecture is replaced by malignant lymphoid follicles in a back-to-back pattern. The inset shows malignant lymphoid follicle germinal centers positive for Bcl-2. What disease?

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Follicular lymphoma

47

Bone marrow biopsy showing infiltration by small to medium-sized lymphocytes with oval to reniform nuclei and pale cytoplasm; circumferential hair projections seen in peripheral blood and bone marrow aspirate smears. What disease?

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Hairy cell leukemia

48

Disease caused by increased megakaryocytes in the bone marrow?

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Idiopathic thrombocytopenic purpura

49

Bcl-1 / Cyclin D1 positive nuclear stain that corresponds to t(11;14). What disease is shown?

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Mantle cell lymphoma

50

"Fried egg" lymphocytes with kidney-shaped nuclei are infiltrating the bone marrow in what disease?

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Hairy cell leukemia

52

Hypercellular bone marrow with granulocytes at various stages of development?

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CML

53

Sheets of large B cells with prominent nucleoli are present in the lymph nodes of what disease?

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Diffuse large B cell lymphoma

55

CD15+, CD30+, CD45-, EBV LMP+ stain. What disease?

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Hodgkin lymphoma

56

Mixed inflammatory background with eosinophils, Reed-Sternberg cells, and lacunar cells. What Hodgkin subtype?

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Nodular sclerosis Hodgkin lymphoma

57

Lymph node effaced by neoplastic lymphocytes with several "starry-sky" macrophages. What disease?

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Burkitt lymphoma

58

Toxoplasmosis with follicular hyperplasia. What are the pink cells?

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Epitheliod macrophages