Protein Synth Inhibitor Abx

Question 1

Inhibitors of Protein Synth =

Answer 1

1) Aminoglycosides: Gentamycin and Tobramycin
2) Tetracyclines: tetracycline and doxy
3) Macrolides: E’mycin, Azithromycin, Clarithromycin
4) Clindamycin
5) Oxazolidinones: Linezolid

Question 2

Aminoglycosides =

Answer 2

Gentamycin and Trobamycin

• Bactericidal against Gram neg pathogens
• Inhibit protein synthesis: Binds to 30S subunit; causes inhibition of initiation complex and misreading of mRNA
• No activity against anaerobes
• IV forms only
• Toxicity can affect renal and 8th cranial nerve

Question 3

Aminoglycosides continued

Answer 3

• Activity is concentration dependent
• Have a post abc effect
• Synergy with B lactams
• Activity against: P aeriginosa, Tularemia, Enterococci + beta lactam; Yersinia

Question 4

Tetracyclines =

Answer 4

Tetracycline, Doxycycline, Tigecycline

Question 5

tetracycline mech of action

Answer 5

• Binds to 30S subunit

- prevents the binding of tRNA to ribosome

Question 6

Tetracylines work against

Answer 6

• wide spectrum
• Intracellular organisms: RIckettsia and Chlamydia
• Cell wall deficient organisms: Mycoplasma
• Bacteriostatic

Question 7

Tigecycline

Answer 7

• Used for drug resistant organisms
• for MRSA, VRE
• Bacteroides and Clostridium: severe intra abdominal infxns
• severe skin infxns

Question 8

Macrolides =

Answer 8

Erithromycin, Azithromycin, and Clarithromycin

Question 9

Macrolide Mech of action

Answer 9

• Binds to 50S subunit
• blocks the translocation of tRNAs
• bacteristatic

Question 10

Erithromycin

Answer 10

• mostly gram + organisms
• similar spectrum to Pen V (strep and staph)
• good choice if allergic to PCN

Question 11

Azithromycin

Answer 11

• Enhanced Gram - coverage
• Good Chlaydia and Mycoplasma
• Good coverage for CAP, otitis, sinusitis