11.7 Inflammatory Bowel Disease

Question 1

two types of IBD

Answer 1

UC and Crohn’s

Question 2

wall involvement in UC

Answer 2

mucosal and submucosal ulcers

Question 3

wall involvement in Crohn’s

Answer 3

full-thickness inflammation with knife-like fissues

Question 4

Begins in rectum and can extend up to cecum (continuous)

Answer 4

UC

Question 5

Can occur anywhere from mouth to anus with skip lesions; terminal ileum is most common site; rectum is least common

Answer 5

Crohn’s

Question 6

UC symptoms

Answer 6

LLQ pain (rectum) with bloody diarrhea

Question 7

Crohn’s symptoms

Answer 7

RLQ pain (ileum) w/ non-bloody diarrhea

Question 8

crypt abscesses with neutrophils on LM

Answer 8

UC

Question 9

Lymphoid aggregates with granulomas on LM

Answer 9

Crohn’s

Question 10

gross appearance of UC

Answer 10

pseudopolyps, loss of haustra; lead pipe sign on imaging

Question 11

gross appearance of Crohn’s

Answer 11

cobbleston mucosa, creeping fat, strictures, string-sign on imagins

Question 12

complications of UC

Answer 12

toxic megacolon and carcinoma

Question 13

risk of carcinoma in UC is based on

Answer 13

extent of colonic involvement and duration of dz

Question 14

complications of Crohn’s

Answer 14

• malabsorption w/ nutritional deficiency
• calcium oxylate kidney stones
• fistula formation
• carcinoma if colon involved

Question 15

UC is associated with what joint problems?

Answer 15

Ankylosing spondylitis,
sacroilitis,
migratory polyarthritis

Question 16

UC is associated w/

Answer 16

• primary sclerosing cholangitis
• pANCA positivity
• joint problems

Question 17

Crohn’s is associated w/

Answer 17

erythema nodosum and uveitis