21. Epidermis Flashcards Preview

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Flashcards in 21. Epidermis Deck (17)
1

Epidermis derived from:
fnx:

ectoderm, barrier

2

deepest layer of epiderms, attaches to BM and has keratinocytis stem cells

Stratum Basal

3

What type of cells are in Basal layer

keratinocytes

4

layer with differentiating keratinocytes, in most parts of body makes up most epiderms, makes keratin

Spinosum

5

What junx hold the epiderms together

Tight jnx, adherenes jnx and DESMOSOMES
then hemidesmosomes from basal to BMX

6

What fibers link all the epidermis together?

keratin intermediate filaments

7

Assembly of Intermediate filaments

Keratin--cleave N and C--> Herodimer of type I and type II--> Tetramer--> protofil--> IF

8

What is in the Granular layer?

keratohyalin grans; key is fillagrin
Lamellar grans; key is ceramies and is fats

9

Composed of corneocytes (lack nucleus) and primary barrier of epidermis

Cornified layer
none on oral, genital and oral
thin on face

10

What is Keratinizaiton

process of keratinocyte migration and maturation
28 days total

11

Where do keratinocytes proliferate

basal layer--> then exit cell cycle go to spinosum

12

Aquired bullous disease d/t autoantibodies to desmoglein 1 and 3

Permphigus Vulgaris

13

where does blistering occur in Pemphigus vulgaris?

Intraepidermal blisters (autoAb to demogelin 1 and 3)

14

Clincally guy comes in with back and oral blisters, they are flacci and rupture easily with nikolky +

Pemphigus vulgaris (desmoglein 1 and 3)

15

TX for Pemphigus Vulgus

Prednisone, Azothiprine, Myco mofetil and Rituximab

16

Autosomal dom; mutation in profillagrin gene--> defective fillagrin gene

Ichthyosis vulgaris

17

SPF =

MEDprocted/MED unprotected
MED = minim amt of UVB causing skin redness at 24 hours