2.1 Metabolic Pathways

Question 1

When does induced fit occur?

Answer 1

Induced fit occurs when the active site changes shape to better fit the substrate after the substrate binds

Question 2

What type of affinity do substrate molecules have?

Answer 2

Substrate molecules have a high affinity for the active site

Question 3

What type of affinity do products have?

Answer 3

Products have a low affinity, allowing them to leave the active site

Question 4

What are competitive inhibitors?

Answer 4

Competitive inhibitors bind at the active site of an enzyme preventing the substrate from binding

Question 5

Can competitive inhibition be reversed?

Answer 5

Competitive inhibition can be reversed by increasing substrate concentration

Question 6

What is a non competitive inhibitor?

Answer 6

Non competitive inhibitors bind away from the active site but change the shape of the active site preventing the substrate from binding

Question 7

Can non competitive inhibition be reversed?

Answer 7

Non competitive inhibition cannot be reversed by increasing substrate concentration

Question 8

What is feedback inhibition?

Answer 8

Feedback inhibition occurs when the end product in the metabolic pathway reaches a critical concentration

Question 9

What does the end product do in feedback inhibition?

Answer 9

The end product inhibits an earlier enzyme, blocking the pathway and so prevents further synthesis of the end product