21 - STI's 1 Flashcards
(71 cards)
1
Q
What STI screening should you do for an asymptomatic patient?
A
Woman
- Self taken vulvo vaginal swab NAAT for C+G
- Bloods for Syphilis, HepB/C, HIV
- Urinalysis/Pregnancy test where appropriate
Man
- First pass Urine for dual NAAT for C+G
- Bloods for Syphilis, HepB/C, HIV
- May need Triple Swabs inc rectal and pharyngeal swabs if MSM
2
Q
What STI screening should you do for a symptomatic patient?
A
Woman
- High Vaginal Swab for microscopy and pH. TV, BV, Candida
- Vulvovaginal Swab for NAAT for C+G
- Bloods
- Urinalysis and Pregnancy test if requested
Man
- Urethral smear GC culture
- First Pass Urine for C+G
- BBV Bloods
- Triple swabs inc pharyngeal and rectal if MSM
- Consider Candia and Herpes swabs
- Urine dip
3
Q
What are the three methods of partner notification?
A
ALWAYS REASSURE PATIENT IT WILL BE ANONYMOUS
- Patient referral: e.g contact card, text, instagram
- Provider referral: GUM clinic contact them
- Contract referral: Pt has agreed time frame to tell partner and if they don’t then GUM will tell them
4
Q
How far do you need to look back for a chlamydia infection for partner notification?
A
6 months
For gonorrhoea it is 3 months
5
Q
How long should partner notification take at maximum for HIV?
A
3 months, ideally should be within 4 weeks
6
Q
How do you assess for BBV?
A
- Paid for sex?
- IV drug user or had sex with IV drug user?
- Had sex with somebody not in this country?
- Sex with bisexual man or man who has sex with men?
7
Q
What is the pathophysiology and causative organism of BV?
A
Gardnerella Vaginalis
Overgrowth of anaerobic vaginal flora due to loss of lactobacilli
Lactobacilli usually produce lactic acid to keep pH<4.5, when pH raises over>4.5 allows anaerobic bacteria to grow
8
Q
What are some risk factors for developing BV?
A
- Multiple sexual partners
- Excessive vaginal cleaning (douching, vaginal washes)
- Recent antibiotics
- Smoking
- Copper coil
9
Q
How does BV present?
A
- Asymptomatic
- Thin grey discharge
- Fishy odour to discharge
- Dysuria
- Dyspareunia
10
Q
How is BV diagnosed?
A
Ix: Speculum, Lateral wall pH, high vaginal charcoal swab, STI screening
Amsel Criteria (3 of 4 need to be met)
- Vaginal pH > 4.5
- Typical discharge
- Positive whiff-amine test: development of fishy odour with addition of 10% potassium hydroxide to vaginal discharge
- Clue cells (on microscopy): vaginal epithelial cells studded with adherent coccobacilli
11
Q
How is BV treated?
A
Metronidazole or Clindamycin
Only treat if symptomatic or if pregnant and having TOP!!!!
- Reduce risk factors
- Oral or intravaginal gel metronidazole for 5-7 days,
12
Q
What are some of the complications with BV?
A
- Increased risk of STIs
- Post surgical infections
- Pregnancy issues: Miscarriage, Preterm deliver, Premature rupture of membranes, Chorioamnionitis, Postpartum endometritis
13
Q
What is the pathophysiology/risk factors for vulvovaginal candidiasis?
A
Candida Albicans (yeast/fungi)
- Oestrogen exposure
- Immunocompromised state (e.g. systemic corticosteroids)
- Poorly controlled diabetes mellitus
- Broad-spectrum antibiotic use: alters the vaginal flora
- Vaginal Hygiene Products
- Sexual activity
- Hormone replacement therapy (HRT)
14
Q
What are some signs and symptoms of thrush?
A
Symptoms
- Vaginal itching and soreness
- Thick white discharge with no odor
- Superficial dyspareunia
- Dysuria
Signs
- Vulvovaginal irritation
- Vaginal fissuring
- Excoritation
15
Q
How is candidiasis investigated and managed?
A
Ix
- Diagnosis can be made on history alone
- Can do vaginal examination
- Can do whiff test, vaginal swab, HbA1c, STI screen, HIV screen if not sure
Mx
- Intravaginal clotrimazole cream or pessary
- Single dose oral Fluconazole
- Topical Clotrimazole 2-3 times per day for vulval symptoms
16
Q
When using anti fungal vaginal creams and pessaries, what information do you need to give a woman?
A
Can damage latex condoms so need additional contraception for at least 5 days after use
17
Q
How is recurrent thrush treated? (4 or more episodes in one year)
A
Induction Maintenance Regime
- Confirm treatment course and adherence
- Reassess risk factors e.g HbA1c
- Consider alternative diagnosis e.g BV or STI
- Consider alternative treatment
18
Q
What is the pathophysiology and causative organism of Trichomoniasis?
A
Trichomonas Vaginalis - Protozoa with flagella
Most common non-viral STI worldwide
Is passed by sexual contact, never MSM though
19
Q
What are the signs and symptoms of Trichomoniasis?
A
Symptoms
- Asymptomatic
- Frothy green-yellow discharge
- Vulval itching or soreness
- Malodorous
- Dysuria
- Abdominal pain
Signs
-
Women:
- Frothy green-yellow discharge
- Vulval inflammation
- Cervical inflammation (often described as ‘strawberry cervix’)
-
Men:
- Usually no signs
- Rarely balanitis
20
Q
How is trichomoniasis investigated and diagnosed?
A
MICROSCOPY FOR DIAGNOSIS!!!!!!
- pH test from lateral wall of vagina will show pH>4.5
- High vaginal swab from posterior fornix for MC+S
- First catch urine or urethral swab from men
- STI screening for other STIs
21
Q
How is trichomoniasis treated?
A
- Oral metronidazole: abstain from sex for 1 week after both themselves and partner treated
- Contact tracing: last 4 weeks needs treatment
22
Q
What are the complications of a trichomoniasis infection?
A
Increased risk of
- Contracting HIV by damaging the vaginal mucosa
- Infertility
- Bacterial vaginosis
- Cervical and prostate cancer
- Pelvic inflammatory disease
- Pregnancy-related complications such as preterm delivery.
23
Q
What is the difference between charcoal swabs and NAAT swabs?
A
Charcoal
- Used for microscopy, culture, sensitivities and gram staining
- Taken endocervical or high vaginal
- Used for organisms shown on image
NAAT
- Used to look for DNA and RNA
- Used for gonorrhoea and chlamydia
- Men: first catch urine or urethral swab
- Women: endocervical, vulvovaginal or first-catch urine
- Can also do pharyngeal and rectal if oral and anal sex
- If test +ve for Gonorrhoea need MC+S charcoal swab to confirm
24
Q
What organism causes Chlamydia and what are the risk factors for this?
A
Chlamydia Trachomatis (Gram Negative Bacteria)
- Age < 25 years
- New sexual partner
- Unprotected sexual intercouse
- ≥1 partner over last year
- Concurrent STI
- Previous STI
25
How does chlamydia present in men and women?
**_Women_**
* USUALLY ASYMPTOMATIC
* Abnormal vaginal discharge
* IMB or PCB
* Deep pelvic pain
* Dyspareunia
* Dysuria
**_Men_**
* Urethral discharge or discomfort
* Dysuria
* Epididymo-orchitis
* Reactive arthritis
26
How is Chlamydia diagnosed and managed?
**_Ix_**
* **NAAT:** either endocervical, vulvovaginal, urethral, first-catch urine, pharyngeal, rectal
**_Mx_**
* **Doxycycline or Azithromycin BD for 7 days**
* If pregnant then Azithromycin 1g stat then 500mg once a day for 2 days
* **Contact trace**
* **Abstain from sex** until treatment done or for 7 days if single dose treatment
* **Test for and treat other STIs**
* **Give advice on how to avoid in the future**
27
What are the complications with a chlamydia infection?
* Epididymo-orchitis
* PID
* Chronic pelvic pain
* Infertility
* Ectopic pregnancy
* Conjunctivitis
* Lymphogranuloma venereum
* Reactive arthritis
Pregnancy-related:
* Preterm delivery
* Premature rupture of membranes
* Low birth weight
* Postpartum endometritis
* Neonatal infection (conjunctivitis and pneumonia)
28
What is Fitz-Hugh Curtis Syndrome and how do you treat it?
Complication of PID, usually Chlamydia
RUQ due to Peri-Hepatitis
Treat with analgesia and antibiotics for underlying PID
29
After treatment for Chlamydia do you need another test?
* Test of cure not recommended if uncomplicated
* If \<25 repeat in 3 months to see if caught it again
* If pregnant or rectal chlamydia need test of cure three weeks after treatment
30
What is Lymphogranuloma Venereum?
Caused by **Chlamydia Trachomatis**
Usually occurs in **MSM population**
Penile papule that turn into shallow **ulcers**
31
What are the different stages of Lymphogranuloma Venereum?
Chlamydia trachomatis serovars L1/L2/L3
## Footnote
**_Primary Stage_**_:_ painless ulcer on penis, vagina or rectum
**_Secondary Stage:_** lymphadenitis, swelling, inflammation and pain in the inguinal and femoral lymph nodes. Groove sign!!!!
**_Tertiary Stage:_** inflammation of the rectum (***proctitis***) and anus. Leads to anal pain, tenesmus, change in bowel habits and anal discharge
32
How is Lymphogranuloma Venereum diagnosed and managed?
**_Ix_**
* **NAAT:** ideally from base of shallow ulcer, if not do urethral/rectal/first catch urine
* **Histology**
* **Serology**
**_Mx_**
* **Three week (21 days) course of doxycycline**
* Avoid sex during treatment
* Contact trace over past 4 weeks - 3 months
33
What are the complications if LGV is left untreated?
* **Lymphoedema**
* **Fistulae**
* **Strictures**
* **Disfiguring fibrotic scarring**
34
Chlamydia can be spread from genitals to the eyes when genital fluid gets in contact with it. How does this present?
Chronic erythema, irritation and discharge lasting more than two weeks
35
What is the pathophysiology and causative organism of Gonorrhoea?
**Neisseria Gonorrhoeae** (Gram Negative Diplococci)
Highest prevalence in MSM
Causes infection of mucous membranes, most notably the urethra, endocervix, rectum, pharynx and conjunctiva. Rarely, it can cause **disseminated infection**
**Causes urethritis, endocervicitis, PID**
36
How do gonorrhoea infections present?
Men usually symptomatic, women usually aymptomatic
**_Women_**
* Odourless purulent discharge, possibly green or yellow
* Dysuria
* Pelvic pain
**_Men_**
* Odourless purulent discharge, possibly green or yellow
* Dysuria
* Testicular pain or swelling (***epididymo-orchitis)***
37
What are some examples of disseminated gonococcal infections?
* Meningitis
* Endocarditis
* Septic arthritis
* Tendinitis
* Fitz Hugh Curtis Syndrome
* PID
* Prostatitis
* Conjuncitvitis
38
How is gonorrhoea diagnosed?
**NAAT:** detect RNA or DNA of gonorrhoea. Endocervical, vulvovaginal or urethral swabs, or in a first-catch urine sample. Rectal and pharyngeal swab are recommended in all MSM
**Charcoal endocervical swab:** microscopy, culture and antibiotic sensitivities before initiating antibiotics. This is particularly important given the high rates of antibiotic resistance
**STI screening:** often confection with Chlamydia
39
How is gonorrhoea managed?
* **If antimicrobial susceptibility unknown:** intramuscular [ceftriaxone](https://bnf.nice.org.uk/drug/ceftriaxone.html)
* **If micro-organism is sensitive to ciprofloxacin:** oral [ciprofloxacin](https://bnf.nice.org.uk/drug/ciprofloxacin.html)
* Contact trace in last 14 days
* Abstain from sex for 7 days and treat partner
* Test for chlamydia co-infection
* TEST OF CURE IS NEEDED
* Provide advice on how to avoid in future
40
Is a test of cure needed with gonorrhoea?
YES!!!! Need NAAT if asymptomatic, culture if symptomatic
Has high antibiotic resistance, especially to Azithromycin so needs it after at least:
* 72 hours after treatment for culture
* 7 days after treatment for RNA NATT
* 14 days after treatment for DNA NATT
41
What are the complications with a gonorrhoea infection?
Opthalmia Neonatorum which can lead to sepsis and blindness in neonate
42
What infection does mycoplasma genitalium cause?
***Non-gonococcal urethritis***
Mycoplasma genitalium infection may lead to:
* Urethritis
* Epididymitis
* Cervicitis
* Endometritis
* Pelvic inflammatory disease
* Reactive arthritis
* Preterm delivery in pregnancy
* Tubal infertility
43
How is non-gonococcal urethritis by MG diagnosed and managed?
Urethritis takes longer to develop with chlamydia (two weeks) than gonorrhoea (days)
**_Ix_**
* **NAAT:** vaginal and first catch urine. If positive need to check for macrolide resistance
**_Mx_**
* **Doxycycline** 100mg twice daily for 7 days then
* Don't use azithromycin anymore due to resistance
* Test of cure not needed
44
What is pelvic inflammatory disease?
Inflammation and infection of the pelvic organs due to **infection spreading up through the cervix**
Cause of **infertility** and **chronic pelvic pain**
45
What are the causes of PID?
**_Common:_**
* Neisseria Gonorrhoeae (severe)
* Chlamydia Trachomatis
* Mycoplasma Genitalium
**_Less Common_**
* Gardnerella Vaginalis
* HiB
* E.Coli
46
What are some risk factors for PID?
* Multiple sexual partners
* Younger age
* Not using condoms
* STIs
* Previous PID
* IUD
47
How may PID present and what examination findings will there be?
**_Symptoms_**
* Pelvic or abdominal pain
* Dysparaenuia
* IMB or PCB
* Fever
* Dysuria
* Abnormal discharge
* RUQ pain
**_Examination_**
* Pelvic and adnexal tenderness
* Cervical motion excitation on bimanual exam
* Cervicitis
* Purulent discharge
48
What investigations should you do if you suspect PID?
Always start empirical antibiotics before test results
* **NAAT** for Gonorrhoea, Chlamydia and MG
* **High vaginal swab** for BV, Trichomoniasis and Candida
* **Microscopy for pus cells**
* **HIV test**
* **Syphillis test**
* **Pregnancy test** to exclude ectopic
* **ESR/CRP**
49
How is PID managed?
START EMPIRICALLY BEFORE SWAB RESULTS
**Doxycycline + Metronidazole for 14 days**
plus
**IM ceftriaxone**
* Need to contact trace
* If signs of sepsis or tuboovarian abscess admit for IV antibiotics and surgical drainage
50
What are some complications of PID left untreated?
* Infertility
* Sepsis
* Abscess
* Chronic pelvic pain
* Fitz-Hugh Curtis Syndrome (Perihepatitis)
* Ectopic Pregnancy
51
What is Fitz-Hugh-Curtis Syndrome and how is it treated?
Complication of PID causing inflammation and infection of the **liver capsule** leading to **adhesions between liver and peritoneum**
**RUQ and right shoulder tip pain**
**_Mx:_** Laparoscopy and Adhesiolysis
52
What drugs are usually used in Chemsex?
Sex under the influence to enhance pleasure. Usually increases risk of BBV as risky behaviour, also ask in BBV risk assessment
* Methamphetamine
* Mephedrone
* GHB/GBL
53
How is epididymo-orchitis treated?
Do US to rule out testicular torsion
Ceftriaxone 1g intramuscularly and Doxycycline 100mg twice daily for 14 days
Where Mycoplasma genitalium has been tested and identified, treatment should be guided to include an appropriate antibiotic (e.g. moxifloxacin)
54
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59
60
61
What are the different methods of inducing labour?
62
63
What are the two main causes of secondary PPH?
* Endometritis
* Retained products of conception
64
What are some reasons for a small fetus?
Small when below the 10th percentile
Do US measurements like AC, Femur length, Head circumference, Umbilical Artery Doppler, Amniotic Fluid volume, MCA doppler
65
What are the risks to the fetus with prematurity?
66
How should PPROM be managed?
* Do TVUS for cervical length (\<15mm likely early labour)
* Do fetal fibronectin test
67
How is preterm labour without PPROM managed?
Magnesium Sulphate is only given if before 32 weeks gestation
68
What is the risk of recurrence of OC with subsequent pregnancies?
50%
69
What is the increase in risk of developing VTE in pregnancy compared to the general population?
5 FOLD
70
71
What is the National Chlamydia Screening Programme?
Aims to screen every sexually active person under 25 years of age for chlamydia ***annually*** or ***when they change their sexual partner***
Everyone that tests positive should have a re-test three months after treatment to check not caught it again
