21.4 NS: Cellular basis of behavioural illness Flashcards

1
Q

What is OCD behaviour linked to changes in?

What happens if we knockout this in mice?

A

Microglia- HoxB8 (knockout=exscessive grooming)

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2
Q

What is the WRT pathway important in?

A

Neuronal development (cell becoming a neuron or glia)

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3
Q

What is abnormal in autism? (3 points)

A
  • Microglia
  • Dorsolateral prefrontal cortex
  • Increase in grey matter density, increase in gre/white volume
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4
Q

What are SNPs in autism a balance between?

A

Protective and risk factors

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