Immunology P 209

Question 1

Cyclosporine MOA, SE

Answer 1

Binds to cyclophilin -> inhibits Calcineurin -> block IL2 secretion

SE: Nephrotoxic, HTN, Hyperlipidemia, Hyperglycemia, Gingival Hyperplasia, Hirsutism

Question 2

Tacrolimus MOA, SE

Answer 2

Binds to FK-binding protein -> inhibit calcineruin -> block IL2 secretion

SE: like cyclosporine, but no Gingival Hyperplasia, Hirsutism

Question 3

Sirolimus

Answer 3

Inhibits mTOR

SE: Hyperlipidemia, Thrombocytopenia, Leukopenia

Question 4

Azathioprine

Answer 4

Antimetabolite of 6MP, block PRPP amidotransferase.

SE: Bone Marrow Suppression. Toxic effect increase w/ Allopurinol

Question 5

Muromonab

Answer 5

Monoclonal Ab, binds to CD3.

SE: cytokine release syndrome.

Question 6

Omalizumab

Answer 6

Blocks IgE

Question 7

Oprelvekin:

Answer 7

TX thrombocytopenia

Question 8

Thrombopoietin:

Answer 8

Tx Thrombocytopenia

Question 9

Filgrastim:

Answer 9

G-CSF (use w/ NRTI)

Question 10

Sargramostim:

Answer 10

GM-CSF

Question 11

IFN-A

Answer 11

HepB/C, Kaposi sarcoma, RCC, leukemias/lymphomas

Question 12

IFN-B

Answer 12

MS

Question 13

IFN-Gamma

Answer 13

CGD