Case 2 (Asia): WCC at 2, 6, 9 months with neuroblastoma Flashcards

1
Q

Well-infant visit: Interval history

A

Any illnesses or problems since the previous visit (if it is the initial visit, include a birth history [details of pregnancy and delivery: illness, medication, substance use, problems with delivery, prenatal labwork, results of newborn hearing screen])

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2
Q

Well-infant visit: Growth assessment

A

Head circumference, weight, and length/height

Best assessed using a growth chart and analyzing the data over time

Babies lose a little weight right after birth, but are expected to be back at a weight >= their birth weight by 2 weeks of age

Average daily weight gain for a term infant is 20–30 grams.

Weight (approximation):

  • Weight at 4 or 5 months=double birth weight
  • Weight at 12 months=triple birth weight

Length (approximation):
- Length at 48 months=double birth length

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3
Q

Well-infant visit: Development assessment

A

At each well visit, physician should assess the four domains of development: Gross motor, fine motor, language/communication and social/behavior.

If child is unable to achieve the milestones in one or any of the four areas at or near the appropriate age, then these areas are of concern for possible delay and further testing or evaluation should be done.

Developmental surveillance:

  • Comparing a child to expected behaviors by age
  • Not as sensitive or specific as developmental screening using a validated tool

Developmental screening:
- Assessment using an evidence-based developmental screening tool to pick up
developmental or behavioral abnormalities. An example is the Parents’Evaluation of Developmental Status (PEDS) for children birth to 8 years
- May take place routinely during well-child visit or at any patient encounter where there are concerns.

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4
Q

Well-infant visit: Diet assessment

A

Breastfeeding or taking formula (if formula, how is it being prepared)

Vitamin D supplementation

Quantity and timing of feeds

Number of wet and soiled diapers per day

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5
Q

Well-infant visit: Social history

A

Who lives with child; who are child’s caregivers

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6
Q

Well-infant visit: Anticipatory guidance

A

A chance to help the parents anticipate child’s development and nutritional needs and to advise them regarding child’s safety. Topics may include:

Child care

Sleep patterns:

  • To prevent sudden infant death syndrome (SIDS), infants must sleep on their backs.
  • Most babies sleep through night by age 4 to 6 months.
  • Infants at 6 months of age usually sleep through the night and take two naps during the day.

Exposure to tobacco smoke

Childproofing the home:

  • Outlet covers, cabinet locks, stair barriers
  • Safe storage of cleaning supplies and medicines
  • Poison control number; place near phone

Use of walkers:
- These are not recommended due to risk of injury, especially when there are stairs in home.

Car seat safety:

  • Infants should be placed, facing the rear, in the middle of the back seat, since that is the most protected part of the automobile.
  • Children < 13 years should not sit in the front seat. The back seat is the safest place.
  • Car seats for children are required by law in all 50 states. Proper use is essential for optimum performance. The most effective car-seat restraint is a five-point harness, consisting of two shoulder straps, a lap belt and a crotch strap.
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7
Q

Well-infant visit: Immunizations (in first 5 years; combo vaccines; influenza immunization recs; side-effects)

A

Within the first five years of life, every child should receive the following vaccines (total number of each):

  • DTaP: Diphtheria, tetanus, and acellular pertussis (5)
  • IPV: Inactivated polio vaccine (4)
  • Hib: Haemophilus influenza Type b (3 or 4, depending on manufacturer)
  • PCV13: Pneumococcal conjugate vaccine, 13 serotypes (4)
  • MMR: Measles, mumps, and rubella (2)
  • Varicella (2)
  • RotaV: Rotavirus (2 or 3, depending on manufacturer)
  • HepA: Hepatitis A (2)
  • HepB: Hepatitis B (3)

Combination vaccines may be used instead of their equivalent component vaccines if licensed and indicated for the patient’s age, (e.g., Pediarix®—which combines the
immunizations for DTaP, HepB, and IPV—and Pentacel®—which combines the DTaP, IPV, and Hib).

Annual influenza immunization recommendations:

  • All children 6 months through 19 years of age
  • Household contacts and out-of-home caregivers of children 0 to 59 months of age
  • Children and adolescents in high-risk groups (e.g., asthma, lung or heart disorders, and immune deficiencies) are higher priority.

Common immunization side effects: Fussiness and fever for 24 hours. If these persist for >24 hours, or more serious side effects, child should be seen right away.

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8
Q

Infant nutrition: Until 4-6 months…; water recs

A

Until age 4–6 months, infants should be given only breast milk or formula.
Plain water should not be given for hydration until infant is eating solid foods.

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9
Q

Infant nutrition: Breast milk recs

A

Preferred source of nutrition

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10
Q

Infant nutrition: Commercial formulas

A

Protein sources: Cow-milk protein, soy protein or hydrolyzed cow’s milk protein. Elemental formulas provide protein in the form of simple amino acids.

Regular cow’s milk not given until age 12 months due to concern for colitis

Formula types: Ready-to-feed (RTF) or those that require mixing prior to feeding (power or formula concentrate). Advise parents to follow package directions carefully when using powder or concentrate, and never to dilute
formula.
- RTF: Given directly to infant from bottle without preparation
- Powder: 2 scoops powder mixed in 4 oz. (1/2 cup) water
- Concentrate: A 1:1 ratio of concentrate to water

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11
Q

Infant nutrition: Caloric requirements of infant

A

Term infants: 100–120 calories/kilogram (kg)/day

Preterm infants: 115–130 calories/kg/day

Very low birth weight (VLBW) infants: Up to 150 calories/kg/day

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12
Q

Infant nutrition: Vitamin D supplementation recs

A

Breastfeeding infants need vitamin D supplementation (formula and milk are already supplemented).

Most cost-effective method is with a multivitamin.

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13
Q

Infant nutrition: Transition to solid foods

A

Typically occurs at ages 4–6 months (for infants born
prematurely, use adjusted age):

Many infants will not be ready for solid foods at 4 months.

Signs that child is ready for solid foods:

  • Able to sit up and keep head up on his/her own
  • Can manipulate pureed foods like rice cereal in mouth (will not spit it out)
  • Shows interest in solid foods (e.g., will open mouth and does not refuse spoon). Start by offering a small amount of iron-fortified infant rice cereal mixed with formula and watch how child accepts it, if at all.
  • Each new food should be introduced only every five to seven days so that allergies can be identified.

Feeding of 9-month-old infant: Requires 100 calories/kg/day, with approximately 75% of calories from breast milk or formula (i.e., 24–28 oz per day)

Can eat strained foods (Stage 2)—which require more chewing—and feed themselves with finger foods, such as toast, crackers, pasta, and banana.

Meats, such as small pieces of chicken, may be started at this age.

Discuss choking hazards with parents. Foods such as popcorn, grapes, hard candies, hot dogs, and jelly candies should never be offered at this age.

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14
Q

Developmental Milestones: 2 months

A

Gross motor:

  • lifts head
  • head up 45 degrees

Fine motor:
- follows to or past midline

Language/Cognitive:
- vocalizes

Social/Personal:

  • smiles responsively
  • smiles spontaneously
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15
Q

Developmental Milestones: 4 months

A

Gross motor:

  • sits with head steady
  • rolls over

Fine motor:

  • follows 180 degrees
  • grasps rattle

Language/Cognitive:

  • laughs
  • turns to rattle sound

Social/Personal:
- regards own hand

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16
Q

Developmental Milestones: 6 months

A

Gross motor:

  • sits without support
  • puts feet in mouth while supine
  • no head lag when pulled to sit from supine

Fine motor:

  • reaches
  • looks for dropped yarn

Language/Cognitive:

  • turns to voice
  • babbles

Social/Personal:

  • works for toy
  • feeds self
  • stranger recognition (prelude to stranger anxiety)
17
Q

Developmental Milestones: 9 months

A

Gross motor:

  • stands holding on
  • pulls to a stand

Fine motor:

  • takes 2 cubes
  • passes cube (transfers)
  • neat pincer grasp

Language/Cognitive:
- single syllables (e.g., “mama,” “dada;” non-specific)

Social/Personal:

  • feeds self
  • plays pat-a-cake
  • indicates want
  • exhibits stranger anxiety
18
Q

Physical Exam: newborn

A

Growth evaluation

  • Head circumference: Measure circumference around widest portion of head, from occipital to frontal area.
  • Weight
  • Length

General: Appearance, activity level, responsiveness

Vital signs:

  • Temperature
  • Respiratory rate
  • Heart rate
  • Blood pressure

Head, eyes, ears, nose, throat (HEENT):
- Anterior fontanelle: Measure and palpate
- Examine red reflex and sclerae:
§ Red reflex is a red/orange color reflected from fundus through pupil when viewed through an ophthalmoscope from about 10 inches away.
§ The red reflex is a substitute for a careful fundoscopic exam, since an infant will not hold gaze long enough to visualize the retina consistently. It gives direct
information about the clarity of the eye structures.
§ A red reflex should be elicited in all infants and children, beginning at birth. Failure to see a red reflex may indicate underlying abnormality (cataracts, glaucoma,
retinoblastoma, or chorioretinitis).
- Nares: Patency, discharge
- Lips: Check color and hydration
- Tympanic membranes: Light reflex, mobility

Neck:
- Suppleness, presence of mass

Chest:
- Lungs: Listen for clarity, breath sounds, symmetry

Heart:
- Rate, rhythm, murmurs

Abdomen:
- Presence/absence of bowel sounds, masses, tenderness, softness, distension

Lymphatics:
- Axillary, inguinal, cervical lymphadenopathy

Hips:
- Ortolani and Barlow maneuvers

Genitalia:
- Normal male/female genitalia

Neurologic:
- Assess tone.
- Symmetry of muscle strength and range of motion
- Moro reflex present and symmetric:
This reflex is elicited by an abrupt change in the infant’s head position and consists of two parts: symmetric abduction and extension of the arms followed by adduction of the arms, sometimes with a cry.
Reflex is present at birth and disappears by age 4 months.
May be used to detect peripheral problems, such as congenital musculoskeletal abnormalities or neural plexus injuries.
- Toes upgoing bilaterally with Babinski maneuver

Skin:
- Examine for rashes, turgor, jaundice, pallor, bruising, petechiae.

Spine/back:
- Check for sacral dimple or hair tuft.

Rectal exam:

  • Not a routine part of infant physical exam, but should be done when intra-abdominal, pelvic or perirectal process suspected.
  • To perform exam in infant, lay infant supine. With one hand, hold feet and flex knees and hips on abdomen. Insert gloved and lubricated index finger of other hand into rectum. Palpate for hard stool and/or a mass.
19
Q

Differential diagnosis: RUQ mass in a thriving and asymptomatic 9 month old female

A
  1. Neuroblastoma: Most frequently diagnosed neoplasm in infants (more than half of patients present before age 2 years). May present as a mass in the neck, chest, or abdomen. Children with an abdominal neuroblastoma may be asymptomatic or may appear chronically ill and have bone pain from metastases to the bone marrow or
    skeleton. Fever, pallor, and weight loss are frequent presenting symptoms. Arises from embryonal cell lines. Most cases of neuroblastoma are due to somatic mutations (arise in cells other than the gametes). In infants less than one year of age, these tumors may spontaneously regress.
  2. Wilms’ tumor: May present as an asymptomatic RUQ abdominal mass without lymphadenopathy or jaundice, growing and developing normally. Masses are generally smooth and rarely cross the midline. Associated symptoms occur in 50% of patients and include abdominal pain and/or vomiting; patients may also be hypertensive. Median age at diagnosis is 3 years.
  3. Teratoma (germ cell tumor): A rare, malignant tumor that can present as a painless abdominal mass with no symptoms (i.e., no jaundice, pallor). As a rare cancer (which in itself is rare in children) it should be on the differential diagnosis even if quite low in the differential. If there are symptoms, they are usually related to pressure effects on neighboring structures and include abdominal or back pain, nausea, vomiting, constipation, and urinary tract symptoms.
  4. Hepatic tumor: Although rare at this age, hepatoblastoma and benign liver tumors must also be considered in a young infant with asymptomatic RUQ abdominal mass. Jaundice may or may not be present.
  5. Hydronephrosis: Obstruction at the uretero-pelvic junction can lead to hydronephrosis and a palpable kidney, which manifests sometimes as a flank mass. May be asymptomatic, although would usually present with a urinary tract infection.
20
Q

Studies for neuroblastoma/RUQ mass differential

A

Complete blood count (CBC) with differential: Use to identify anemia and also to look for cytopenia that may be associated with bone marrow infiltration; test is not specific for any one diagnosis.

Urinary vanillylmandelic acid/homovanillic acid (VMA/HVA): Measures metabolites of catecholamines, which are elevated in neuroblastoma. This test is highly specific for neuroblastoma and can be 90–95% sensitive in detecting neuroblastoma.

Chest x-ray: Can identify metastases to the chest.

Skeletal survey (x-ray): Will identify metastases to the bone.

Technetium-99 bone scan: The radionuclide bone scan is more accurate than either conventional radiographic studies or physical examination in localizing tumors.

Bone marrow aspiration/biopsy: Bone marrow aspirations identify marrow involvement. Rosettes of small, uniform cells containing dense, hyperchromatic nuclei and scant
cytoplasm (small-cell rosettes) in bone marrow are diagnostic for neuroblastoma.

21
Q

Management of neuroblastoma

A
  1. Referral to oncologist
  2. Tumor staging
  3. Family meeting with oncologist, nurse coordinator, and social worker to discuss prognosis and treatment options, care coordination
  4. Resection versus observation of primary tumor and metastases
  5. Long-term follow-up for recurrence