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Pathology > Integumentary Terms (Path Final) > Flashcards

Integumentary Terms (Path Final) Flashcards

1
Q

Acantholysis

A

loss of cohesion btwn keratinocytes caused by the breakdown of intercellular bridges

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2
Q

Acanthosis

A

thickening of the spinous cell layer (stratum spinosum) of the epidermis

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3
Q

Acral

A

distal parts of the extremities

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4
Q

Anagen

A

phase in which hair synthesis takes place

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5
Q

Anaplasia

A

lack of cellular differentiation & organization, a feature of neoplastic cells

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6
Q

Angioedema

A

vascular reaction involving the deep dermis or subcutis & consistitng of edema manifested as giant wheals & caused by dilation & increased permeability of capillaries

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7
Q

Angioedema is a deeper version of what?

A

Urticaria

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8
Q

Ballooning degeneration

A

marked intracellular fluid accumulation in the cells of the epidermis

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9
Q

Blister

A

localized collection of fluid usually in or beneath the epidermis

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10
Q

A blister is also known as what? (2)

A

vesicle or bulla

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11
Q

Bulla

A

Blister > or = to 1.0 cm

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12
Q

Carinoma in situ

A

malignant neoplasm of epithelial origin that has not invaded through the basement membrane

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13
Q

Catagen

A

Transition phase of the hair cyle; btwn growth & resting phase

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14
Q

Cellulitis

A

acute bacT infection of the dermis & subcutis that spreads to surrounding soft tissues

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15
Q

What are the characteristics of Cellulitis? (6)

A 
erythema
warmth
swelling
pain
fever 
enlarged lymph nodes
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16
Q

What is often the source of infection for Cellulitis?

A

penetrating wound in the area of infection

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17
Q

Comedo (pl= comedones)

A

plug of follicular stratum corneum & dried sebum in a hair follicle that leads to follicular distention

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18
Q

Cornification

A

Production of stratum corneum by terminal epidermal differentiation

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19
Q

Material formed by drying of exudate or secretion on the skin surface

A

crust

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20
Q

Small molecular wt. protein (< 30 kD) that are mediators of inflammation & growth

A

Cytokines

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21
Q

Naturally pigmented black or brown mycelium or conidium

A

Dematiaceous

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22
Q

Infection of the stratum corneum of the epidermis, hair or claws with fungi of the genera Microsporum, Epidermophyton, or Trichophyton

A

Dermatophytosis

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23
Q

Noninflammatory lesion of the skin

A

Dermatosis

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24
Q

Dandruff

A

Detritus

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25
Q

Abnormal, premature or imperfect keratinization

A

Dyskeratosis

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26
Q

Abnormal development

A

Dysplasia

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27
Q

Shedding of hair

A

Effluvium

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28
Q

Degeneration of dermal C.T. leading to accumulation of elastotic fibers

A

Elastosis

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29
Q

When is elastosis sometimes seen?

A

w/ solar dermatitis

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30
Q

peripheral expanding ring of scale

A

Epidermal Collarette

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31
Q

Inflammation of the epidermis

A

Epidermitis

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32
Q

Separation of the epidermis from the dermis

A

Epidermolysis

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33
Q

Have a predilection to enter the epidermis or other epithelial structures as seen with cutaneous T-cell lymphoma (mycosis fungoides)

A

Epidermotropic or Epitheliotropic

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34
Q

Loss of the superficial layers of the epidermis

A

Erosion

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35
Q

Rapid development of skin lesion associated w/ redness

A

Eruption

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36
Q

Redness of the skin caused by congestion of capillaries

A

Erythema

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37
Q

Superficial loss of epidermal layers caused by physical trauma (scratching)

A

Excoriation

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38
Q

Shedding of layers or scales

A

Exfoliation

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39
Q

Stage in which old hairs are shed in the hair cycle

A

Exogen

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40
Q

Fluid, cells or debris from blood vessels deposited in or on other tissues

A

Exudate

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41
Q

Cleft or groove

A

Fissure

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42
Q

Inflammation of a hair follicle

A

Folliculitis

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43
Q

Circumscribed, painful node (accumulation of pus) in the dermis 2ry to follicular rupture

A

Furuncle

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44
Q

Rupture of follicles usually caused by inflammation, distention &/or trauma to entry of follicular contents into the dermis

A

Furunculosis

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45
Q

A genetically determined disorder of the skin

A

Genodermatosis

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46
Q

smooth skin, hairless skin

A

Glabrous

47
Q

A localized, tumor-like malformation of mature cells & tissue that includes normal components of the organ in which the hamartoma arises but that is disorganized, present in excess & sometimes larger than normal.

A

Hamartoma

48
Q

Is a hamartoma a true neoplasm?

A

No, b/c it involves the proliferation of more than one cell type & often includes the development of complex structures such as arteries or follicles

49
Q

Intracellular fluid accumulation in cells of the basal epidermis

A

Hydropic degeneration

50
Q

Thickening of the stratum corneum

A

Hyperkeratosis

51
Q

Incomplete development

A

Hypoplasia

52
Q

Less hair than normal

A

Hypotrichosis

53
Q

Congenital skin disorder in which the skin is thickened by scales (hyperkeratosis) that can crack into plates resembling fish scales

A

Ichthyosis

54
Q

Bacterial dermatitis characterized by pustules

A

Impetigo

55
Q

Slow growing; persistent ulcers on the lips of cats

A

Indolent

56
Q

Hardening of the skin as a result of inflammation or fibrosis

A

Indurated

57
Q

Inflammation arranged in a layer close to & often obscurring the epidermal-dermal jxn & w/ vacuolated & sometimes apoptotic basal cells. Can be mild or extensive

A

Interface

58
Q

Dermatitis that develops b/c of friction btwn apposing skin surfaces

A

Intertrigo

59
Q

Epidermal cells that synthesize keratin & comprise more than 90% of epidermal cells

A

Keratinocytes

60
Q

Uncommon to rare circumscribed paular, plaque-like, or linear focus of proliferative keratinocytes covered by thick stratum corneum

A

Keratosis (pl. Keratoses)

61
Q

What can cause keratosis? (2)

A

Sun exposure

Idiopathic

62
Q

An intense focal folliculitis usually caused by a dermatophyte infection

A

Kerion

63
Q

Intraepidermal dendritic APCs

A

Langerhans’ cells

64
Q

Thickening of skin w/ accentuation of skin creases caused by marked acanthosis

A

Lichenification

65
Q

Generally refers to a dense zone of dermal inflammation parallel to the epidermis usually w/o basal cell injury

A

Lichenoid

66
Q

Uncommon to rare, often idiopathic, single or grouped papules, plaques or papillomatous foci covered by scale

A

Lichenoid dermatosis

67
Q

Histologically composed of epidermal hyperplasia, lichenoid lymphoplasmacytic dermal inflammation, hyperkeratosis & parakeratosis

A

Lichenoid dermatosis

68
Q

Flat, circumscribed lesion of altered skin color

A

Macule

69
Q

Dark granular pigment produced by melanocytes that is responsible for the brown coloration of hair, skin & other tissues

A

Melanin

70
Q

Macrophage containing ingested melanin

A

Melanophage

71
Q

A neuroendocrine cell found in the stratum basale

A

Merkel Cell

72
Q

Glycosaminoglycan (GAG), normal component of intercellular ground substance of the deris; consists of protein bound to hyaluronic acid

A

Mucin

73
Q

A mass of hyphae

A

Mycelium

74
Q

Slowly progressive infection of the cutaneous & SQ tissue, fascia & sometimes underlying bone caused by traumatic implantation of actinomycetes or fungi

A

Mycetoma

75
Q

Traumatic implantation of actinomycetes

A

Actinomycotic mycetoma

76
Q

Traumatic implantation of fungi

A

Eumycotic mycetoma

77
Q

Non-pitting edema of the skin b/c of abnormal deposits of mucin in the dermis

A

Myxedema

78
Q

Ac acute lif-threatening subtype of cellulitis usually caused by Strep. infection & toxin production. Located w/in the SQ fat & fascial planes

A

Necrotizing fasciitis

79
Q

What are the appearance of the gross lesions of necrotizing fasciitis?

A

Painful, hot & swollen areas w/ entensive exudation & necrosis

80
Q

What can Necrotizing fasciitis progress to?

A

can progress rapidly to shock

81
Q

Circumscribed malformation of the skin assumed to be of congenital or inherited origin & consisting of any component of the skin

A

Nevus

82
Q

Which term is preferred over nevus?

A

Hamartoma

83
Q

A circumscribed, solid elevation of skin (> 1cm)

A

Nodule

84
Q

Abnormal formation of the claw

A

Onychodystrophy

85
Q

Sloughing of the claws

A

Oncychomadesis

86
Q

Inflammation of SQ adipose tissue

A

Panniculitis

87
Q

Circumscribed, solid elevation of skin (< 1cm)

A

Papule

88
Q

Retention of pyknotic nuclei in epidermal cells of the stratum corneum

A

Parakeratosis

89
Q

Inflammation of skin around the claws

A

Paronychia

90
Q

A localized intraepidermal collection of neoplastic lymphocytes characterisitic of epitheliotropuc lymphoma (mycosis fungoides)

A

Pautrier’s Microabscess

91
Q

A group of cutaneous dz’s associated w/ blistering

A

Pemphigus

92
Q

Mycotic dz caused by pigmented fungi of a variety of genera & species that do not form sclerotic bodies or gransules

A

Phaeohyphomycosis

93
Q

Melanin pigment w/in dermal macrophages or free in the dermis developing via injury to pigment containing basal layer cells

A

Pigmentary Incontinence

94
Q

Flat-topped, solid elevation in the skin that occupies a relatively large surface area in comparison w/ its height (> 1 cm)

A

Plaque

95
Q

Itching

A

Pruritus

96
Q

Small, circumscribed accumulation of pus w/in the epidermis or w/in a hair follicle

A

Pustule

97
Q

Pyogenic bacterial infection of the skin

A

Pyoderma

98
Q

Term from human med; used to define an ulcerative basal cell carcinoma

A

Rodent ulcer

99
Q

Which term is often incorrectly used in Vet Med to describe an indolent ulcer affecting the lips of cats?

A

Rodent Ulcer

100
Q

Thin, platelike accumulation of stratum corneum on the surface of the skin

A

Scale

101
Q

Nonspecific term for C.S. of scaling, crusting & greasiness

A

Seborrhea

102
Q

More specific term, applied to inherited cornification disorders

A

Primary seborrhea

103
Q

Secretion of the sebaceous glands

A

Sebum

104
Q

Intercellular edema, which, by widening of the intercellular space & stretching of the “intercellular bridges” creates a sponge-like appearance to the epidermis

A

Spongiosis

105
Q

Resting phase of the hair cycle

A

Telogen

106
Q

Full thickness loss of the epidermis w/ extension into the dermis

A

Ulcer

107
Q

Usually transient vascular rxn in the upper dermis consisting of edema manifested clinically as wheals; more superficial version of angioedema

A

Urticaria

108
Q

What is another term for wheals?

A

Hives

109
Q

Small blister w/in the epidermis or at or below the dermal-epidermal interface (<1.0 cm)

A

Vesicle

110
Q

Long, coarse hair located above the nose

A

Vibrissa

111
Q

Acquired disorder characterized by circumscribed areas of depigmentation in the skin

A

Vitilido

112
Q

Smooth, circumscribed, slightly elevated area on the skin caused by dermal edema

A

Wheal

113
Q

Unicellular budding fungus

A

Yeast

Pathology (13 decks)

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