2.2:4 Absorption of drugs from the GIT: Kinetics

Question 1

In first order kinetics , what is the rate of absorption proportional to?

Answer 1

The amount of drug remaining to be absorbed

Question 2

What is Ka?

Answer 2

Absorption rate constant

The rate of emptying relative to the amount of drug remaining in the lumen will remain constant

Question 3

Define this equation: Rate of absorption= Ka X Aa

Answer 3

Ka:Absorption rate constant
Aa: Amount remaining to be asborbed

Question 4

Remember: t1/2,ab = 0.693/kab

Answer 4

.

Question 5

Remember:

Rate of elimination= CL x C
Total amount eliminated + CL x AUC

For a drug administered orally:
FX dose = CL x AUC
Total amount absorbed = total amount emilinated
(what is not absorbed cannot be eliminated)

Answer 5

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