Moa Flashcards
Competitive antagonist of BZD at GABAa receptor
Flumazenil
ALT: doxopram, nicetamide
Has a GABA mimetic activity by acting in the BZD receptor at GABA receptor CI complex, thus prolonging the inhibitory effects of GABA
Benzodiazepines
Enhance GABA’s acxn by binding to a different site on the GABA receptor-chloride channel, but less specific than BZD
Barbiturates
Partial agonist at brain 5-HT1a receptor
Buspirone
For generalized anxiety stage
Not a BZD but act on the same site as BZD
Zolpidem
-pure hynotic acxn
Enhances GABA at GABAa receptor,
Inhibits the ability of glutamate to open the cation channel assoc w/ NMDA(N-methyl-D-Aspartate) subtype of glutamate receptor
Alcohol
H1 receptor antagonist
Antihistamine
Inhibition of phosphodiesterase thus inc cAMP; inc Ca permeability; blocks adenosine receptors
Methylxanthines
+ chrono and inotropic effects on heart
Stops MAO, inc rel. of NE
Amphetamines
Has the ability to to have vasoconstriction by itself; potentiates and prolongs CNS and peripheral acxns of cathecolamine
Cocaine
-intense euphoria
Inhibits reuptake of DOPA, SE and NE
PCP “angel dust”
-Analog of ketamine
Interacts w/ several 5HT receptor subtypes in the brain
LSD
-w brilliant color SE
Inc reuptake of Ne into adrenergic nerve endings and dec the rel of NE; alters cellular conc of IP3
Lithium
Activate the myocardial beta1 receptor and thus inc the force of contraction of the failing heart; inc CO
Dopamine and dobutamine
Used in CHF
Displace NE from presynaptic terminals and bind to adrenergic receptors
Mixes sympathomimetics