2 lytic viruses

Question 1

whaet is the nucleic acid of picornavirus?

Answer 1

ssRNA +

Question 2

does picornavirus have a lipid envelope?

Answer 2

no?

Question 3

do Picoviruses have a lipid envelope?

do they have a tegment?

Answer 3

no

no

Question 4

at what pH do rhinoviruses start to become unstable?

when are entero viruses stable?

Answer 4

below 6

enteroviruses are stable at a pH from 3-9

Question 5

what shape is a picornavirus?

Answer 5

icosahedral

Question 6

what does enterovirus cause?

Answer 6

paralysis (non-polio and polio-type), common cold, meningitis, diarrhea,

hand-foot-and-mouth disease.

Question 7

what does the rhinovirus cuase?

Answer 7

the common cold.

Question 8

hepatovirus what does it cause?

Answer 8

hepatitis

Question 9

what is the transmission of enteroviruses?

Answer 9

fecal oral routes.

the capsid is resistant to water treatment.

Question 10

what are the diffrent forms of polio?

Answer 10

Question 11

what is poliomyelitis? what happens in it?

Answer 11

polios=gray myelos=marrow itis=inflammation

more effect on lower extremeties.

with a slow recovery over 2 years.

there may be some residual paraylis.

Question 12

what is the progression of polio like?

Answer 12

it may be asymptomatic or may progress to minor or major diseases.

Question 13

what was the endemic stage of polio?

what is the epidemic stage of polio?

what is teh post vaccine phase of polio?

Answer 13

when the children would encounter the virus at an early age they would still have the maternal antibodies that would protect them.

in the 1900s there was indoor plumbing everywhere and people would be older when they first started encountering the virus/.

there is very few cases. most are vaccine related.

Question 14

what is the path of infection of polio?

Answer 14

it binds to the receptor and enters.

it is uncoated

it is translated without the cap.

makes a single polypeptide.

it is is self cleaved with some to make the capsid and some non structure protein.

Question 15

how does the polio virus get in?

Answer 15

through endocytosis and then the RNA is injected into it.

Question 16

what is the effect of the polio on the host cell?

Answer 16

it inhibits translation and that plays a role in cell death.

Question 17

what are teh steps that picorna viruses need to take to make copies of its genome?

Answer 17

it takes its ssRNA + and has to make a - copy and uses that to make a replicate + copy.

Question 18

what are 3 diffrent strategys or things to inhibit the picornavirus?

Answer 18

Virusentryandgenomerelease(Pleconaril)

ProteaseProcessing(Ruprintrivir)

• RNA-dependent RNA polymerase inhibitors (Ribavirin)

Question 19

what did salk invent?

Answer 19

the inactivated virus vaccine 1955

sabin made the live attenuated virus. in 1962

Question 20

what kind of nucleic acid does the adenovirus have?

does it have an envelope?

how is it spread?

where is it a latent virus?

Answer 20

dsDNA

not enveloped.

it is spread through the fecal oral route.

latent virus in the adenoids and tonsils.

Question 21

The Adenovirus particle is a much more

complicated machine than the

picornavirus particle.

Answer 21

Question 22

what are the diseases that adenovirus causes?

Answer 22

it is a gastrointestional disease

that affects mostly the immunosupressed.

have vommiting fever before diarrhea.

it has a similar trophism to picornavirus but it is much different.

Question 23

how does the adenovirus get into the blood causing a viremia?

Answer 23

it goes into the lymphnodes

Question 24

how is the adenovirus released from the epithelia cells?

Answer 24

the virus makes more of itself and goes and makes protein that disrupts tthe adhesion junctions.

Question 25

Adenovirus Gene Expression Is Quite Complex

Answer 25

• not simple partitioning into early and late segments
• clusters of genes are expressed from a limited number of shared promoters

multiple spliced mRNA and alternative splicing are used to make a variety of poly peptides from each promoter.

Question 26

is there a adenovirus vaccine?

Answer 26

yes.