Endocrine

Question 1

Zoledronic Acid

Answer 1

Biphosphonate
Zometa. Aclasta 5mg/100mL
OP, hypercalcemia of malginacy, pagets, prevention of corticosteroid induce BMD loss
IV 5mg yearly
plasma concentrations of calcium, phosphate and magnesium
serum creatine
Drink 2 glasses of water before and after infusion
dentist

Question 2

Risedronate

Answer 2

biphosphonate
Paget’s disease of bone, T of OP, T&P of corticosteroid-induced OP
Renal
Actonel
5 mg once daily or 35 mg once a week or 150 mg once a month
DCC. L3B - mane - full glass of water. remain upright for 30minutes. (Ec- with or without food) L4.
Stop tablets and see your doctor immediately if you have pain on swallowing, or new or worsening heartburn
Dental

Question 3

Strontium ranelate

Answer 3

Other drugs affecting bone.
Protos. 2g sachet nocte
Renal. MI. severe allergy. VTE.
Bedtime. 2hours post eating.

Question 4

Teriparatide

Answer 4

Other drugs affecting bone.
20mcg sc d.
Only use for 18months. - osteo carsimona

Question 5

Raloxifene

Answer 5

Other drugs affecting bone. (Evista)
P&T Postmenopausal OP
Primary prevention of invasive breast cancer in high-risk postmenopausal women
Cat X.,
hot flushes, sweating, leg cramps, peripheral oedema, sleep disorders
60mg once daily

Question 6

Sitagliptin

Answer 6

100mg D.

CrCl 30–50 mL/minute, 50 mg once daily

Question 7

Glipizide
Glibenclamide
Glicalzide
Glimepride

Answer 7

minidab - 2.5–40 mg d- bd
2.5 -20
CR:30-120 IT:40-320
Amaryl - 1-4mg daily

Question 8

Exenatide

Answer 8

Glucagon like peptide-1 analogue. 5-10mcg bd. 2mg/weekly
see doc - if abdo pain.
with 60minutes before meal. Nausea, vommitting and diarrohea. - fluids.

Question 9

Acarbose

Answer 9

other drugs for diabetes
50-100mg tds. with food
swallow whole. diarrohea. flatulence. abdo pain.

Question 10

Carbimazole

Answer 10

antithyroid drug.
5-45mg bd-tds dosing
itch
tell your doc is mouth ulcers

Question 11

Cinacalcet

Answer 11

Other drugs for bone. hyperparathyoird. 30mg d to 90mg bd.
renal. phosphate. calcium parathyroid.
with food for best absorption. tell your doc if smoking changes

Question 12

Denosumab

Answer 12

Prolia. Other drugs affecting bones or RANKL blocker.
60mg q6mth.
calcium
tell dentist.

Question 13

Raloxifene

Answer 13

Evista. Oestrogen agonist. postmenopause. OP. 60mg daily. VTE. Cat X

Question 14

Cabergoline

Bromocriptine

Answer 14

Dopamine Agonist.
Postpartum Lactation Suppression. Parkinsons.
Hallucinations and confusion
0.5-1mg. L12

2.5 BD. nocte