FA 2014: Hem Drugs

Question 1

LMWHs

Answer 1

Enoxaparin, dalteparin, fondaparinux

Question 2

Mechanism of HIT

Answer 2

IgG against Heparin:PF4 –> thrombocytopenia

Question 3

Treatment of HIT

Answer 3

Direct thrombin inhibitors (argatroban, bivalirudin, leupridin)

Question 4

Direct factor Xa inhibitors

Answer 4

Apixaban, rivaroxaban

Question 5

Direct thrombin inhibitors

Answer 5

Argatroban, bivalirudin, leupridin

Question 6

Mechanism of heparin

Answer 6

Heparin –> antithrombin –> decreased IIa/Xa

Question 7

Treatment for thrombolytic tox

Answer 7

Aminocaproic acid

Question 8

Treatment for heparin tox

Answer 8

Protamine sulfate

Question 9

ASA effect on clotting

Answer 9

Elevated bleeding time, no effect on PT/PTT

Question 10

ASA toxicity

Answer 10

Gastric ulceration, tinnitus, interstitial nephritis, Reye syndrome

Resp alkalosis –> metabolic acidosis

Question 11

ADP receptor inhibitors

Answer 11

Clopidogrel (Plavix), ticlopidine, prasugrel, ticagrelor

Question 12

Neutropenia in patient taking stroke prophylaxis

Answer 12

Ticlopidine effect

Question 13

Mechanism of ADP-R inhibitors

Answer 13

Inhibit platelet aggregation, fibrinogen binding by preventing GpIIb/IIIa binding

Question 14

PDE-III inhibitors

Answer 14

Cilostazol, dipyridamole

Question 15

Mechanism of PDE-III inhibitors

Answer 15

Raise cAMP in platelets –| aggregation, vasodilators

Question 16

Use of PDE-III inhibitors

Answer 16

Intermittent claudication, TIA/stroke prevention, angina prophylaxis

Question 17

GPIIb/IIIa inhibitors

Answer 17

Abciximab, eptifibatide, tirofiban

Question 18

Use of GPIIb/IIIa inhibitors

Answer 18

Unstable angina, PCI angioplasty

Question 19

Toxicity of GPIIb/IIIa inhibitors

Answer 19

Thrombocytopenia, bleeding