Principles of Hemostasis Flashcards
What are the proteins that inhibit the clotting cascade?
TFPI
ATIII
Protein C, Protein S
What are the proteins that promote clot lysis?
t-PA
Plasmin
Alpha granules consist of
Fibrinogen, vWF
Delta granules consist of
Serotonin, ADP, Ca2+
What is the role of phospholipids in the clotting cascade?
Activate coagulation factors
What is the role of GP Ia in the clotting cascade?
Binds collagen
What is the role of GP Ib in the clotting cascade?
Binds vWF
What is the role of GP IIb-IIIa in the clotting cascade?
Binds fibrinogen
What protein is the “added” protein in the extrinsic pathway?
Tissue factor
What factors are involved in the intrinsic pathway?
XII, XI, IX, VIII
What factors are involved in the extrinsic pathway?
TF, VII
What factors are involved in the final common pathway?
V, X, prothrombin/thrombin, fibrinogen/fibrin
Where does tissue factor come from?
Hidden cells exposed during injury
Microparticles floating in blood
Endothelial cells and monocytes
What activates factor VII?
Nothing, it’s just kinda there
What happens as soon as Xa is made?
Extrinsic pathway shuts down
