Seronegative arthropathies

Question 1

Name two dermatological manifestations of reactive arthritis

Answer 1

• Keratoderma blennorrhagica

- Circinate balanitis

Question 2

Name two dermatological manifestations of enteropathic arthritis

Answer 2

• Erythema nodosum

- Pyoderma gangernosum

Question 3

Name five common characteristics of the seronegative arthropathies

Answer 3

• Absence of rheumatoid factor
• Sacro-iliac joint involvement
• Enthesopathy
• Anterior uveitis (iritis)
• HLA B27 association

Question 4

What % of Caucasians with ankylosing spondylitis are HLA-B27 positive?

Answer 4

Approx. 95%

Question 5

What % of patients with AS develop peripheral joint involvement?

Answer 5

appox. 20%

Question 6

What are the five different types of psoriatic arthritis?

Answer 6

1) Asymmetrical oligo- or polyarthritis
2) Spondyloarthropathy
3) Predominantly DIP joint disease/dactylitis
4) Rheumatoid-like/ rheumatoid pattern
5) Arthritis mutilans (5%)

Question 7

How do you manage the spondyloarthropathy sub-type of psoriatic arthritis?

Answer 7

In the same way as ank spond. This group develop a disease which is indistinguishable from ank spond, but in the presence of psoriatic skin disease.

Question 8

What three organisms of the GU tract are commonly implicated in reactive arthritis?

Answer 8

1) Chlamydia trachomatis
2) Neisseria gonorrhoeae
3) Mycoplasma fermentens

Question 9

What five organisms of the GI tract are commonly implicated in reactive arthritis?

Answer 9

1) Salmonella enteritidis
2) Campylobacter jejuni
3) Cryptosporidium
4) Shigella flexneri
5) Enterotoxigenic E.coli