L9

Question 1

myogenic response

Answer 1

afferent arteriole smooth muscle contracts when sstretched and relaxes on lowering distending pressure

• mediated by stretch sensitive cation channels
• efferent arterioles do not seem to respond to changes in stretch and therefore do not contribute to myogenic response

Question 2

tgf

Answer 2

changes in gfr induced by changes in the flow rate of the fuluid perfusing the macula densa, because macula densa senses increase in concentration NaCl (increase in rate of NKCC2 transporters, which increases Ca or cell volume and leads to release of ATP)
-more sensitive with volume contraction (and rise in plasma A2) and less sensitive with volume expansion

Question 3

GT balance

Answer 3

increase in in filtration of Na, increase in reabsorption in proximal tubule, loop of henle, and distal tubule

Question 4

What is the equation for RPF

Answer 4

=C pah

=(1-HCT) x RBF

Question 5

Eqn for FF

Answer 5

GFR/RPF

Question 6

How would you calculate how much solute is reabsorbed

Answer 6

Filtered - excreted

PxGFR - UxV

Question 7

If glomerular disease lowered GFR by reducing surface area, what is the auto regulatory response

Answer 7

TGF causes renin release