Receptors Flashcards

1
Q

alpha one

A
  • increase vascular smooth muscle contraction
  • pupillary dilator muscle
  • intestinal and bladder spinchter contraction
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2
Q

alpha two

A

decrease sympathetic outflow
decrease insulin release
decrease lipolysis
increase platelet aggregation

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3
Q

beta one

A

increase hr
increase contracility
increase renin
increase lipolysis

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4
Q

beta two

A

vasodilation, bronchodilation
increase hr, contractility, lipolysis
increase aqueous humor production

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5
Q

N receptors

A

ligand gated Na/K channels

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6
Q

M1

A

CNS

enteric nerve system

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7
Q

M2

A

decrease heart rate and contractility of atria

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8
Q

M3

A
increase exocrine gland secretions
increase gut perstaliss
increase bladder contraction
bronchoconstriction
increase pupillary sphinct muscler (miosis)
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9
Q

M receptor - classes

A

M1 - q
M2 - i
M3 - q

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10
Q

a/b Receptor Classes

A

a1 - q
a2 - i
b1 - s
b2 - s

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11
Q

D/H/V receptor classes

A

D - si
H - qs
V - qs

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12
Q

D1

A

relaxes RENAL vascular smooth muscle

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13
Q

D2

A

modulates transmitter release, esp in brain

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14
Q

H1

A

increases nashal and bronchial mucus production

contraction of bronchioles, pruritis, pain

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15
Q

H2

A

increase gastric acid secretion

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16
Q

V1

A

increases vascular smooth muscle contraction

17
Q

V2

A

increases H202 permeability and reabsorption in collection tubules of the kidney

18
Q

Gq

A

phopholipase c –> DAG + IP3
DAG –> protein kinase C
IP3 –> increase Ca in –> smooth muscle contraction

19
Q

Gs/or/i

A

adenylyl cyclase –> camp –> protein kinase A
increase Ca (heart)
myosin light chian kinase (smooth msucle)

20
Q

parts of SNS innervated by cholinergic fibers

A

adrenal medulla

sweat glands

21
Q

Synthesis of NE

A

tyrosine –> dopa –> dopamine –> NE –> Epi

22
Q

Botulinium toxin

A

prevents ach release from synaptic vesicles

23
Q

Cocaine

A

inhibits NE reuptake

24
Q

TCA

A

inhibts NE reuptake

25
Q

Amphetamine

A

inhibts NE reuptake