Isoproterenol Flashcards
Isoproterenol Classification
Sympathomimetic
Isoproterenol Names
Isuprel, isuprel mistometer, norisodrine aerotrol sulfate
Isoproterenol MOA
- Drug induced stimulation of beta-1 receptors results in:
i. Increased cardiac output by increasing the strength of cardiac contractions and increasing heart rate (increase SBP) - Drug induced stimulation of beta-2 receptors results in:
i. Dilates the arterioles of skeletal muscle, resulting in decreased PVR (decreased diastolic BP)
ii. Relaxes bronchiole smooth muscles
iii. Facilitates removal of pulmonary secretions by increasing ciliary motion
Isoproterenol Indications
- Symptomatic Bradycardia refractory to atropine when TCP is not available or an option
- Bronchodilation in asthma, COPD, and other conditions involving bronchi spasms
- Beta Blocker OD (May require higher dose)
Isoproterenol Contraindications
- Cardiogenic shock
- Angina
- Tachydysrhythmias and heart blocks associated with digitalis OD
- Ventricular arrhythmias
Isoproterenol Side Effects
Cardiovascular: flushing, palpitations, unstable BP, tachycardia, ventricular dysrhythmias
CNS: headache, tremors, anxiety, nervousness
Isoproterenol Precautions
Use with extreme caution in patients with known or suspects electrolyte imbalance, due to propensity for dysrhythmias
Isoproterenol Interactions
Oxytocic Drugs (pitocin, oxytocin) - possibity of sever HTN; Tricyclic Antidepressents- potentiation of pressor effect; Beta Blocking drives will antagonize the effects of Isoproterenol
Isoproterenol Routes of Admin
IVPB, IV, IO (can also be given via HHN or MDI)
Isoproterenol Onset and Duration of Action
Inhalation: 2-5 min with peak effect I’m 3-5 min lasting for 30-120 min
Iv: Immediate lasting less than an hours
Isoproterenol Dosages
Symptomatic Bradycardia:
Adult : 2-10 mcg/min IVP/IVPB titrated to desired heart rate
Peds: 0.1 mcg/min IVP/IVPB titrated to desired heart rate
Bronchospasms:
Adult: 1-2 inhalations of MDI
Peds: 1-2 inhalations of MDI
