24.10

Question 1

Histology of inactive thyroid gland?

Answer 1

Low cuboidal cells

Colloid in follicle

Question 2

Histology of active thyroid gland?

Answer 2

Tall cuboidal to columnar cells

“Scalloping” of colloid

Question 3

What are two important causes of hypothyroidism?

Answer 3

Iodine deficiency

Hashimoto thyroiditis - due to autoimmune damage to the thyroid

Question 4

Diffuse non-toxic or simple goitre involves an increase in ___ and results in ___ increase in size of thyroid gland.

Answer 4

TSH

Diffuse

Question 5

Histology of diffuse non-toxic “simple” goitre?

Answer 5

Hyperplastic
Crowding of cells lining follicles
Some follicles are larger than others
There can be large colloid-filled cysts

Question 6

If there is no resolution of simple goitre and there is continuously high TSH, it can progress to ___ goitre.

Answer 6

Multinodular

Question 7

In the progression of simple to multinodular goitre, some follicles grow into large nodules, and some ___ and ___.
You can see haemosiderin, calcification and cholesterol clefts.

Answer 7

Rupture and fibrose