Chapter 18: MSK

Question 1

Impaired cartilage proliferation in the growth plate - due to an ACTIVATING mutation of FGFR3.

Answer 1

Achondroplasia

Question 2

Autosomal dominant defect in collagen type I synthesis

Answer 2

Osteogenesis imperfecta

Question 3

Mutation in Carbonic anhydrase II. Anemia, thrombocytopenia, leukopenia, hydrocephalus and renal tubular acidosis.

Answer 3

Osteopetrosis

Question 4

Defective mineralization of osteoid due to low levels of vitamin D. Low serum Ca na phosphate, high PTH and alkaline phosphatase

Answer 4

Rickets/osteomalacia

Question 5

Reduction in Trabecular bone mass. Bone pain and fractures in weight-bearing areas. Serum Ca, PO3, PTH and alk phosphatase are nml.

Answer 5

Osteoporosis

Question 6

Thick, sclerotic bone that fractures easily - mosaic patter of lamellar bone. Increasing hat size. Isolated elevated alkaline phosphatase.

Answer 6

Paget Disease of Bone.

Question 7

Bone Pain, fever, leukocytosis, abscess. Most ocmmon cause is S. auresus.

Answer 7

Osteomyelitis