Protein Synthesis Inhibitors

Question 1

Name 3 mechanisms for protein synthesis inhibtors

Answer 1

1. Block 30S
2. Block 50S
3. Translation inhibitors

Question 2

Name 2 classes of drugs that block the 30S

Answer 2

1. Aminoglycosides

2. Tetracyclines

Question 3

Name 2 Aminoglycosides
STATIC or CIDAL
Downside

Answer 3

1. Streptomycin
2. Gentamicin
   CIDAL
   Ineffective in anaerobic conditions or acid

Question 4

Streptomycin is effective against

Answer 4

MTB & S. aureus

Question 5

Gentamicin is effective against

Answer 5

-

Question 6

Side effect of gentamycin

Answer 6

Ototoxic

Question 7

Tetracylins target
Side effect
STATIC or CIDAL

Answer 7

Prevent aminoacyl-RNA binding to 30S
Discolors teeth
Static

Question 8

Name 3 tetracyclines

Answer 8

1. Tetracycline
2. Doxycyclin
3. Minocycline

Question 9

Name 4 drugs that block 50S subunit

Answer 9

AC²E
A: Azithromycin
C: Chloramphenicol
C: Clindamycin
E: Erythromycin

Question 10

Name 3 drugs that block 50S subunit and are thought to be effective against MRSA, VREF

Answer 10

STreptogramins
Dalfopristin
Quinupristin

Question 11

All of the drugs that block 50 S subunit are CIDAL OR STATIC

Answer 11

STATIC

Question 12

Name 2 translation inhibitors

STATIC OR CIDAL

Answer 12

Linezolid & Muprocin

STATIC

Question 13

Which translation inhibitor is thought to be effective against MRSA & VREF

Answer 13

Linezolid

Question 14

Which translation inhibitor block isoleucyl-tRNA synthetase

Answer 14

Muprocin