Clinical biochemistry Flashcards
What does ALT stand for?
alanine aminotransferase
What is the deficiency in Von Gierke’s disease?
glucose 6-phosphatase deficiency
Which stays elevated longer (AST or ALT) and is a better indicator of chronicity of the condition?
ALT (longer half-life)
What is the active carrier of glucose?
UDP-glucose
In a patient with acute pancreatitis, which enzyme would you expect to find elevated?
lipase
Where is alkaline phosphatase located?
liver, bone, biliary tract, epithelium, intestinal mucosa, and placenta
Does ethanol metabolism lead to hypo- or hyperglycemia?
hypoglycemia
Describe several circumstances that could cause AST elevation.
following MI, liver disease or injury, liver tumor or abscess, cirrhosis, hepatitis, drug or EtOH damage
Under what circumstances would GGT be elevated?
active liver dz (acute damage or biliary obstruction)
Out of ALP, GGT, AST, and ALT which enzyme would help to determine if the disease process was associated with bone?
ALP
What does AST stand for?
aspartate aminotranserase
What is the primary problem in maple syrup urine disease?
block in degradation of branched amino acids
What does GGT stand for?
gamma glutamyltransferase
