Cardiovascular Flashcards
truncus arteriosus
ascending aorta and pulmonary trunk
bulbus cordis
smooth part (outflow tract) of left and right ventricles
primitive atria
trabeculated part of left and right atria
primitive ventricle
trabeculated part of left and right ventricles
primitive pulmonary vein
smooth part of left atrium
left horn of sinus venosus
coronary sinus
right horn of sinus venosus
smooth part of right atrium
right common cardinal vein and right anterior cardinal vein
SVC
heart morphogenesis
first functional organ (beats spontaneously at 4 weeks)
cardiac looping
heart tube elongates on the right side (first visual sign of left-right asymmetry)
begins 4 weeks gestation
dextrocardia
dextrocardia of embryonic arrest - heart is further right in thorax than is normal
dextrocardia situs inveersus - heart is mirror image on right side
steps of separation of chambers - atria
- septum primum grows toward endocardial cushions, narrowing foramen primum
- foramen secundum forms in septum primum (foramen primum disappears)
- septum secundum develops as foramen secundum maintains right-to-left shunt
- septum secundum expands and covers most of the foramen secundum (the residual foramen is the foramen ovale)
- remaining portion of septum primum forms valve of foramen oval
- septum secundum and septum primum fuse to form the atrial septum
- foramen ovale closes soon after birth due to increased LA pressure
patent foramen ovale
casued by failure of the septum primum and septum secundum to fuse after birth (generally left untreated)
can lead to paradoxical emboli - venous thromboemboli that enter systemic arterial circulation
paradoxical embolism
potentially caused by patent foramen oval
NORMALLY - emboli from veins enter right side of heart and move to lungs = pulmonary embolism
WITH PATENT FORAMEN OVALE - emboli can pass directly from venous circulation to arterial circulation and may enter brain = stroke
steps of separation of chambers - ventricles
- muscular ventricular septum forms - opening is called interventricular foramen
- aorticopulmonary septum rotates and fuses with muscular ventricular system to form membranous interventricular septum, closing interventricular foramen
- growth of endocardial cushions separates atria from ventricles and contributes to both atrial separation and membranous portion of the interventricular septum
ventricular septal defect
most commonly occurs in membranous septum
acyanotic at birth due to left-right shunt
acyanotic congenital heart defects
“3 D’s”
- VSD
- ASD
- PDA
cyanotic congenital heart defects
“5 T’s”
- truncus arteriosus
- transposition of the great vessels
- tricuspid atresia
- tetralogy of fallot
- total anomalous pulmonary venous return
outflow tract formation
- truncus arteriosus rotates - neural crest an endocardial cell migrations
- truncal and bulbar ridges that spiral and fuse to form aortic pulmonary septum - ascending aorta and pulmonary trunk
conotruncal abnormalities
- transposition of the great vessels
- tetralogy of fallot
- persistent truncus arteriosus
fetal erythropoiesis (when is blood being produced)
“Young Liver Synthesizes Blood”
- Yolk sac (3-8 weeks)
- Liver (6 weeks - birth)
- Spleen (10-28 weeks)
- Bone marrow (18 weeks - adult)
fetal hemoglobin
HbF (alpha2gamma2)
higher affinity for oxygen than adult hemoglobin due to less avid binding of 2,3-BPG (allows fetal hemoglobin to extract oxygen from maternal hemoglobin (HbA - alpha2beta2) across the placenta
“alpha always, gamma goes, becomes beta”
fetal circulation
blood in umbilical arteries (mixed/unoxygenated blood from aorta) has low O2 saturation
blood in umbilical veins has PO2 of 30mmHg and is 80% saturated (oxygenated at placenta)
fetal circulation - shunts
- ductus venosus - blood entering fetus from the placenta (in umbilical veins) bypasses hepatic circulation via ductus venous (moves directly in IVC)
- foramen ovale - highly oxygenated blood reaching the right atrium from the placenta (via IVC) passes from right atrium to left atrium through the foramen oval (pumped out the aorta to the head and body)
- ductus arteriosus - blood exiting the right ventricle passes directly from the pulmonary artery to the aorta through the ductus arteriosus (high fetal pulmonary artery resistance)
circulation changes at birth
- fetus takes first breath = decreased resistance in pulmonary vasculature = increased left atrial pressure as compared to right atrial pressure (more blood entering left side from lungs now) = foramen ovale closes (FOSSA OVALIS)
- increased oxygen (from respiration) and decreased prostaglandins from (placental separation) cause closure of the ductus arteriosus (LIGAMENTUM ARTERIOSUM)
- **INDOMETHACIN helps close patent ductus arteriosus
- **PROSTAGLANDINS E1 and E2 maintain PDA
umbilical vein
ligamentum teres heaptis (contained in falciform ligament)
umbiLical arteries
mediaL umbilical ligaments
ductus arteriosus
ligamentum arteriosum
ductus venosus
ligamentum venosum
foramen ovale
fossa ovalis
allaNtois
mediaN umbilical ligament
notochord
nucleus pulposus of intervertebral disc