Retina Flashcards

1
Q

What is visual acuity?

A

the ability to resolve fine detail

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2
Q

What factors limit visual acuity?

A

neural factors

optical factors

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3
Q

How do we test visual acuity?

A

recognition of letters on a Snellen or LogMAR chart

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4
Q

What does 6/60 and 6/12 mean?

A

these individuals can see at 6m what a normal person sees at 60m = legally blind
can see at 6m what a normal person sees at 12m -> needed for driving

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5
Q

What are the optical factors affecting VA?

A

Pupil size
Clarity of the optical media (ie how transparent the cornea is)
Refractive errors (error in focussing of the light by the eye)

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6
Q

What is scotopic vision? what photoreceptors are most active?

A

low light levels (ie darkness) RODS are responsible for vision

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7
Q

What are the neural factors affecting VA?

A

?

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8
Q

What is photopic vision? what photoreceptors are involved?

A

vision under well lit conditions -due to CONES

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9
Q

What is the structure of the retina - name the 6 types of neurons involved

A

Layered structure with 6 types of neurons -> Ganglion cells, Bipolar cells, Horizontal cells, Amacrine Cells, Rods and Cones

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10
Q

What are the photoreceptor cells? where are they located?

A

Rods & Cones

Located in the last layer of the retina furtherest from the light source.

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11
Q

What are the two synaptic layers of the retina called?

A

Outer plexiform layer, and Inner plexiform layer

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12
Q

What do Rods do?

A

function in dim light & provide black and white vision. Only 1 type, Very sensitive and NOT found in the fovea

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13
Q

What do Cones do?

A

function in well lit conditions and are involved in the perception of colour. 3 Types (red, green, blue), less sensitive and densest in the fovea

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14
Q

Are there more rods or cones in the retina? which ones is bigger?

A

RODS outnumber Cones 20:1

Cones are bigger

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15
Q

What are the main layers of the retina?

A

GC layer, Inner plexiform layer, Inner nuclear layer, Outer plexiform layer, outer nuclear layer, Photoreceptor layer, Pigmented epithelium

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16
Q

What is the general pathway through the 6 different neuron types in the retina?

A

photoreceptors synapse with bipolar cells which synpase with GCs, and HC and AC create lateral interactions at each synapse (HC between Ph +BCs, and AC between BC + GCs)

17
Q

How are bipolar cells classified?

A

10 different types: depending on whether they receive signals from Rods (1 type) or Cones (9 types)

18
Q

What is the response of BCs when light falls on the retina?

A

OFF BCs - hyperpolarise

ON BCs - depolarise

19
Q

How do horizontal cells function?

A

receive input from and provide input to photoreceptors. use GABA (inhibitory) - respond to light be HYPERPOLARISING

20
Q

How do Amacrine cells function?

A

axonless cells that are important for lateral inhibition - release glycine and GABA onto bipolar and GCs

21
Q

What is unique about the GCs?

A

only neuron in the retina that fires action potentials, release glutamate

22
Q

What is the receptive field or a cell?

A

area of retina that when stimulated with light changes that cell’s membrane potential

23
Q

What are photopigments?

A

proteins that change conformation when light hits it

24
Q

What photopigments do Rods contain?

A

Rhodopsin

25
Q

What photopigments do Cones contain?

A

3 different kinds of cone-opsins

26
Q

What is the role of Vit A in vision?

A

Vit A binds opsins (photopigments) -> essentiat for photoreceptor function

27
Q

What happens to photoreceptors when light hits them?

A

respond to light with graded changes in membrane potential -> become hyperpolarised -> so they release LESS glutamate released

28
Q

What is the mechanism by which photoreceptors become hyperpolarised in response to light?

A

light activates rhodopsin which leads to a siganlling pathway resulting in PDE activation which breaks down cGMP to GMP- stopping the cGMP mediated opening of the Na channel -> this stops Na+ influx into the photoreceptor -> hyperpolarized (more negative)