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Pediatrics > Hematology > Flashcards

Hematology Flashcards

0
Q

Peripheral smear findings in HUS

A

Schistocytes and burr cells, minimal platelets

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1
Q

Triad of hemolytic anemia, thrombocytopenia, and acute renal failure

A

HUS

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2
Q

Fetal hemoglobin takes over at

A

12 weeks gestation (gone by 12 months)

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3
Q

Red cell lifespan in newborn

A

45-60 days

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4
Q

Hypersegmented PMNs

A

Megaloblastic anemia (B12, folate)

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5
Q

Basophilic stippling

A

Lead poisoning

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6
Q

Howell Jolly bodies

A

Functional asplenia

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7
Q

Schistocytes

A

Microangiopathy

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8
Q

Spherocytes

A

Spherocytosis, AIHA

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9
Q

Target cells

A

Thalassemia, liver disease

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10
Q

Teardrops

A

MDS

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11
Q

Burr cells

A

Uremia vs. liver disease

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12
Q

Mentzer index less than 12

A

Thalassemia

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13
Q

Mentzer index above 12

A

Iron deficiency

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14
Q

How to calculate Mentzer index

A

MCV/RBC

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15
Q

Newborn screen only with hemoglobin F

A

Beta thalassemia major (tx with stem cell transplant)

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16
Q

Goats milk is deficient in

A

Folate

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17
Q

Vegans are deficient in

A

B12

18
Q

Mode of inheritance for spherocytosis

A

AD

19
Q

Normalcy tic anemia with reticulocytosis and increased MCHC

A

Spherocytosis

20
Q

Gold standard test to diagnose spherocytosis

A

Osmotic fragility

21
Q

Patients with spherocytosis s/p splenectomy still at risk for

A

Cholelithiasis

22
Q

Mode of inheritance of G6PD Deficiency

A

X linked AR

23
Q

Can cause G6PD problems

A

Fava beans, sulfonamides, antimalarials, moth balls

24
Q

Bite cells and blister cells

A

G6PD Deficiency

25
Q

Assay for CD59 or FLAER tests for

A

Paroxysmal Nocturnal Hemoglobinuria

26
Q

ELA2 gene, chronically low ANC, risk of AML/MDS, G-CSF is tx of choice, AR

A

Kostmann’s Syndrome (severe congenital neutropenia)

27
Q

Severe neutropenia, GI symptoms, AR

A

Shwachman Diamond Syndrome

28
Q

Diagnose CGD with

A

NBT test

29
Q

AR, oculocutaneous albinism, neutropenia, prolonged bleeding, increased infections

A

Chediak Higashi

30
Q

IgE level over 1,000, cold skin abscesses 2/2 staph aureus, need bactrim ppx

A

Job Syndrome (hyper immunoglobulin E)

31
Q

Pentad of TTP

A

MAHA, neurologic symptoms, renal dysfunction, thrombocytopenia, fever

32
Q

Thrombocytopenia, absent radii, normal thumbs

A

TAR syndrome, AR

33
Q

X linked, thrombocytopenia, severe eczema, immunodeficiency, SMALL platelets,

A

Wiskott Aldrich. SCT is curative

34
Q

AR, thrombocytopenia with GIANT platelets

A

Bernard Soulier Syndrome

35
Q

Normal platelet count, severe bleeding and bruising

A

Glanzmann’s Thrombasthenia. Tx with platelet transfusion

36
Q

Large hemangioma with DIC

A

Kasabach Merrit

37
Q

AR, no thumbs, short, anemia or thrombocytopenia, risk of AML

A

Fanconi Anemia. Defective DNA repair

38
Q

Normal red cell adenosine deaminase, HgB 6-8.

A

Transient Erythroblastopenia of Childhood. Self limited. May be 2/2 viral infection. Just monitor

39
Q

Short, webbed neck, heart disease, anemia, renal anomalies, hypotonia dims, glaucoma, MR. Abnormal red cell adenosine deaminase

A

Diamond Blackfan Anemia. SCT for steroid refractory pts

40
Q

Lyric punched out lesion on skull, external otitis that does not respond to antibiotics (draining ears). May have floating teeth or bad dermatitis

A

Langerhan’s Cell Histiocytosis

41
Q

Hyperlipidemia, hyperferritinemia, fever, HSM, CNS symptoms

A

HLH (Hemophagocytic Lymphohistiocytosis). Tx with etoposide

42
Q

Mode of inheritance of Hemophilia A

A

X linked recessive

Pediatrics (20 decks)

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