Hematology Flashcards

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1
Q

a HEME PREPARATION will repress

A

ALA synthase

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2
Q

Deficiency of what RBC enzymes has the same PP as G6PD?

A

glutathione reductase

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3
Q

Blood parameter not related to hemoglobin function

A

blood partial pressure of O2

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4
Q

Methemoglobinemia presentation

A

causes a dusky discoloration of the skin, functional anemia

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5
Q

absent expression of PECAM 1 gene will affect the neutrophilic function of

A

transmigration

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6
Q

Deficient flow pathway in G6PD

A

G6P to 6PG

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7
Q

To cause fetal hemolysis, maternal antibodies must be

A

predominantly IgM

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8
Q

Baby with megaloblastic anemia and high plasma homocysteine levels. Unable to form methylcobalamin. Synthesis of what substance is ML impaired?

A

methionine

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9
Q

Rx: long term anticoagulant to prevent venous thrombosis and resultant pulmonary embolism

A

warfarin

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10
Q

drug of choice for acute mgmy VT or TE

A

heparin

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11
Q

Patients with chronic hemolytic anemia are predisposed to

A

folic acid deficiency and macrocytic changes due to increased erythrocyte turnover

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12
Q

hemloytic anemia, a hypercoagulable state, and decreased blood counts

A

PNH

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13
Q

intrvascular hemolytic anemias are characterized by

A

decreased serum haptoglobin, increased Hgb, LDH, bilirubin

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14
Q

Most helpful for the consideration of spherocytosis

A

Increased MCHC, because of mild dehydration of the RBC

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15
Q

Spherocytosis- highest risk for developing

A

pigmented gallstones (complication of any hemolytic anemia)

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16
Q

Helpful in hx for T vs B cell ALL

A

T cell ALL presents as a mediastial mass that can cause respi sx, dysphagia, or superior vena cava syndrome

17
Q

In the lungs, Hgb binds O2 and releases protons; tissues…

A

releases O2 and acquires protons

18
Q

Raltegravir

A

integrase inhibitor that disrupts the ability of HIV to integrate its genome into the host cell’s chromosomes

19
Q

NNRTI’s

A

arv drigs that do not require activation via intracellular phosphorylation.

20
Q

more common NNRTI’s

A

nevirapine, efavirenz, delaviridine

21
Q

Normal bell shaped curve: percentage within one standard deviation of the mean

A

68%

22
Q

% of obs within two SD’s of mean

A

95%

23
Q

within 3 SD’s of the mean

A

99.7%

24
Q

Increases immediately once Vit B12 is administered

A

retic count