2011 BII exam

Question 1

Types of cytokines

Answer 1

Adaptive immune response cytokines
Chemokines
Haematopoietic cytokines

Question 2

Adaptive immune response

Answer 2

IL-1 - second messenger to activate T cells following contact with antigen
IL-2 - stimulates clonal proliferation of antigen-specific T cells
IFN-gamma - causes activation of macrophages, promotes HLA expression, activates NK cells
IL-4, IL-5, IL-6 - stimulate growth and differentiation of B cells

Question 3

Chemokines

Answer 3

IL-8 (CXC chemokine) - influences neutrophil chemotaxis and activation
MCP-1 and MIP-1alpha (C-C chemokines) - important role in allergic inflammation by stimulating basophils to release histamine

Question 4

Haematopoietic cytokines

Answer 4

IL-3 - proliferation of all lineages of haematopoietic cells
G-CSF, M-CSF, GM-CSF
IL-5 eosinophil growth and activation of important allergic responses
IL-7 erythroblast and megakaryocyte growth and B cell development