Thyroid Pathology

Question 1

Describe pathology of Euthyroid Thyroids

Answer 1

Follicles of irregular size, large amounts of colloid, hyperplastic and crowded cells

Question 2

Describe pathology of Grave’s Disease

Answer 2

Lymphocye infiltration, scalloping of colloid, columnar cells and Pale colloid

Question 3

Describe pathology of Hashimoto’s Disease

Answer 3

Lymphocytic infiltrate, germinal centres, fibrosis and Hürthle cell

Question 4

Describe multi-nodular thyroid

Answer 4

irregular follicle sizes, increased colloid, hyperplastic and crowded epithelial cells with ruptured follicles, fibrosis, cholesterol clefts, heamorrhage and heamosiderin

Question 5

What is a Hürthle cell?

Answer 5

Have abudant eosinophillic charateristics with granular cytoplasm

Question 6

Macro of Hasimotos

Answer 6

Enlarged at first then becomes atrophic, when cut is like an unripe pear and is a tan yellow and very pale. Presence of nodules sometimes present

Question 7

Macro of graves

Answer 7

Diffuse enlargement of gland, cut surface is soft and meaty

Question 8

Why do patients develop exopthalmia

Answer 8

Similar TSH receptor on fibroblasts in the eye that leads to the deposition of GAGs etc, Thisn leads to water attrtaciton and the area around the eye ball will increase with water and swell leading to the condition. Also the fibroblast will also take on the appearance of adipocytes and hence also fat depoisition around the eye