Lab 5 - Inflammation, Tissue regeneration & repair

Question 1

Blood

Answer 1

fluid in the CV system

Question 2

Plasma

Answer 2

fluid portion of the blood in which particulate components (proteins) are suspended

Question 3

Serum

Answer 3

cellular free portion of blood from which fibrinogen has been separated

Question 4

Filtrate

Answer 4

liquid that passes through a filter (i.e. renal filtrate -> urine)

Question 5

Trasnudate

Answer 5

Ultrafiltrate of blood plasma that has passes from BV into tissues due to a change in hydrostatic pressure (passive movement through a filter system)

Question 6

Exudate

Answer 6

Protein-rick fluid, often contain inflammatory cells & cellular debris (active process with many components -> exuding things like pus), result of inflammation

Different types
Purulent = pus/dead neutrophils
Fibrinous =fibrin & fibrinogen

Serous (Tb) low protein, resembles serum

Question 7

5 cardinal signs of inflammation

Answer 7

Dolor 		        Pain
Calor 		        Heat
Rubor 		        Redness 
Tumor 		        Swelling
Functio laesa	Loss of Function

Question 8

Granulation Tissue

Answer 8

• new CT (fibrblasts) with tiny BV that form on surfaces of wounds during the healing process
• Grows from basal to apical
• Results in scarring

Question 9

Granuloma

Answer 9

Type of chronic inflammation; immune system attempts to wall off substances that it perceives as foreign but unable to eliminate

Defined by histiocytes and macrophages that fuse to form giant cells (Langhans giant cell)

Question 10

Primary Intention

Answer 10

Sutured/glued together -> re-approximated

Minimized scarring

Question 11

Secondary Intention

Answer 11

Avulsion/burn/DC Ulcers/wound packed with gauze or drainage system
Broader scarring
Slower process due to presence of drainage/infection – need wound care
Allowed granulation tissue to form

Question 12

Keloid

Answer 12

Out of control scarring
Overgrowth of granulation tissue (collagen III)

vs. Hypertrophic scars:
raised scars that do not go beyond the boundaries of the original wound

Question 13

C-reactive protein Test

Answer 13

Nonspecific, just means there is an inflammatory process going on

Question 14

ESR (Erythrosedimentation rate)

Answer 14

Nonspecific, rate that RBC settle

-elevated = increase in proteins in the plasma 8,000-10,000 - involves

Question 15

Leukocyte Count

Answer 15

Elevated WBC = Incudes Neutrophils, lymphocytes, monocytes, eosinophils, basophils

Question 16

SPEP (Serum Protein Electrophoresis)

Answer 16

Increased a-1 & a-2