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Pharm 2 > Class 1 Deck 2 > Flashcards

Class 1 Deck 2 Flashcards

1
Q

In the absence of neuromuscular blockers, acetylcholinesterase inhibitors may produce what?

A

Fasiculations

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2
Q

At doses greater than usual clinical doses, anticholinesterase drugs have been reported to produce some form of what?

A

neuromuscular blockade

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3
Q

In what 3 ways can Anticholinesterase Drugs be classified?

A
  • Reversible inhibition
  • Formation of carbamyl esters
  • Irreversible inhibition
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4
Q

What is the onset of action for the Anticholinesterase Drugs?

A
  • Edrophonium 1-2 minutes
  • Neostigmine 7-11 minutes
  • Pyridostigmine up to 16 minutes
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5
Q

What drug should be used with edrophonium and why?

A

-Atropine, because edrophonium works so fast and glycopyrolate is slower onset.

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6
Q

What are the muscarinic effects of Anticholinesterase Drugs?

A
  • Bradycardia
  • Salivation
  • Bronchoconstriction
  • miosis
  • hyperperistalsis
  • PONV
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7
Q

What 2 Anticholinesterase Drugs that produce marked inhibition of plasma cholinesterase? Why is this important?

A
  • Neostigmine
  • Pyridostigmine
  • Prolongs succs
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8
Q

What are the 4 clinical uses of Anticholinesterase Drugs?

A
  • Reversal of neuromuscular blockade
  • Treatment of CNS effects
  • Treat myasthenia gravis
  • Treatment glaucoma
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9
Q

Name the Anticholinesterase Drugs in order of fastest to slowest.

A

Edro-neo-pyrido

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10
Q

Anticholinesterase Drug potency depends on what 4 things?

A
  • NMB drug being antagonized
  • Speed of spontaneous recovery
  • Depth of NMB when reversal is initiated
  • End point selected
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11
Q

3 things to know about physostigmine.

A
  • Tertiary amine (crosses BBB)
  • Antagonizes CNS effects of certain drugs
  • Dose 15-60mcg/kg
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12
Q

What drugs can physostigmine reverse?

A
  • Anitcholinergic drugs
  • Opiods
  • Benzos
  • Anesthetics
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13
Q

What are the muscarinic effects of Anticholinesterase Drug overdose?

A
  • Miosis
  • Salivation
  • Bronchospsam
  • Bradycardia
  • ABD cramps
  • loss of bowel bladder control
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14
Q

What are the nicotinic effects of Anticholinesterase Drug overdose?

A

Skeletal muscle weakness (paralysis/apnea)

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15
Q

What are the CNS effects of Anticholinesterase Drug overdose?

A
  • Confusion
  • Ataxia
  • Seizure
  • Coma
  • Depressed ventillation
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16
Q

How to treat Anticholinesterase Drug overdose.

A
  • Atropine (antimuscarinic)

- Pralidoxime (Acetylcholinesterase reactivator)

Pharm 2 (23 decks)

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