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Cardio 2 > Angina drugs > Flashcards

Angina drugs Flashcards

1
Q

nitrate vasodilators

A

NTG

isosorbide dinirrate

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2
Q

CaCh Blockers

A

verapamil
diltiazem
DHPs

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3
Q

DHPs

A

Nifedipeine
amlodipine
felodipine

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4
Q

Beta blockers

A

atenolol
metoprolol
propranolol

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5
Q

antiplatelet agents

A

asiprin
clopidorgrel
reasugrel
IIa/IIIb inhibitors

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6
Q

IIa/IIIb inhibitors

A

abciximab
tirofibran
eptifibatide

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7
Q

anticoagulants

A

heparin

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8
Q

chronic coronary artery disease/stable angina

A 
aspirin
beta blockers
nitragtes
CaCh blockers
ACE inhibitors
Ranolazine
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9
Q

Acute coronary syndromes

A

aspirin
beta blockers
nitrates

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10
Q

acute w/no ST elevation

A

heparin + GPIIb-IIIa inhibitors +
ADP R blocker
or
bivalirudin + ADP R blocker

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11
Q

STEMI thrombolysis

A

thrombolytic agent
heparin
ADP R blocker

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12
Q

STEMI angioplasty

A

heparin + GPIIb-IIIa inhibitors +
ADP R blocker
or
bivalirudin + ADP R blocker

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13
Q

Post MI management

A 
statin
ACE inhibitor
aldosterone receptor antagonist
aspirin
ADP R antagonist
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14
Q

typical angina

A

induced by exercise
alleviated by NTG
lasts no longer then 15min, 5-15 episodes/week
ST segment depression

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15
Q

unstable angina

A

if symptoms not relieved by 3 NTG tablets w/in 15min should call 911/get to ED asap

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16
Q

treatment of typical angina

A

beta blockers + aspirin (clopidogrel if aspirin not tollerated)
can also add long-acting nitrate
Nitrate for acute attacks
ACE inhib in diabetes or left ventricular dysfunction
long acting DHP when beta blocker contraindicated, not working, or causing intolerable side effects

17
Q

unstable angina treatment

A 
MONA
beta blocker
if beta blocker contrainidcated use verapamil or diltiazem
aspirin + heparin
PCI
cbg
thrombolytics
18
Q

MONA

A

morphine
O2
NTG
ASA

19
Q

Thrombolytics

A

alteplase
reteplase
tenecteplase
streptokinase

20
Q

NO

A

increases cGMP

21
Q

Isosorbide dinitrate

A

long acting vasodilator

22
Q

adverse effects of vasodilators

A

headaches
facial flush
dizziness
orthostatic hypotension (worse w/ethanol)

23
Q

nitrate limitations

A

tolerance
must have 8hr/day drug free
drug holidays

24
Q

nitrates contraindications

A

in AMI avoid if RV infarction

patients on erectile dysfunction drugs dangerous fall in BP

25
Q

Non DHPs

A

verapamil
diltiazem
primarily cardiac effects

26
Q

DHPs

A

vasodilatory effects
Nifedipine
amlodipine
felodipine

27
Q

CaCh blocker over all effects

A

cause neg inotropic effect, but concurrent drop in TPR can cause drop in BP activating barorecptor reflex increasing HR

28
Q

non-DHPs actioin

A

drop rate of SA node depolarization and decrease AV nodal conduction

29
Q

All CCBs

A

decrease coronary vascular resistance and increase coronary blood flow

30
Q

CCB toxcity

A 
excessive vasodilation-dizziness, hypotension, headache, flushing, nausea
verapamil- constipation
peripheral edema
coughing
wheezing
pulmonary edema
coronary steal
31
Q

CCB contraindications

A

nonDHPs cannot be used w/beta blocker ->AV block
SA, AV nodal conduction defects
systolic pressure <90

32
Q

clopidogrel

A

slectively inhibits ADPRs
irreversible long term inhibition of platelet aggregation
useful for unstable angina, prevention and Tx of TIA and stroke
stent replacement

33
Q

abciximab

A

used during angioplasty

monoclonal Ab against GPIIb/IIIaR

34
Q

other angioplasty drugs

A

tirofiban
eptifibatide
inhibit ligand binding to IIb/IIIa R

35
Q

acute prophylaxis and Tx of single attacks

A

NTG

36
Q

maintenance therapy of chronic stable angina

A

beta blockers, CCBs, or long duration nitrates or combo

37
Q

vasospastic angina

A

CCB or nitrates

Cardio 2 (17 decks)

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