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Dermatology Block > Bullous Diseases > Flashcards

Bullous Diseases Flashcards

1
Q

Features of HSV1

A

Primary-painful vesicles on labial mucosa, secondary-grouped vesicles on an erythematous base

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2
Q

Features of HSV2

A

Primary-bilateral erosions, inguinal LAD; secondary-grouped erosions, shorter duration

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3
Q

Features of varicella zoster

A

Teardrop vesicle on erythematous base

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4
Q

Complications of VZV

A

Pneumonia, ataxia, encephalitis, Reye’s syndrome

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5
Q

Features of HZV

A

Occurs unilaterally along a dermatome, papules/plaques => blisters, disseminated in elderly/immunocompromised

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6
Q

Treatment of HSV and VZV

A

Acyclovir and valacyclovir

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7
Q

Features of bullous pemphigoid

A

Tense bullae on urticarial base

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8
Q

Epidemiology of bullous pemphigoid

A

Elderly 65-75 yo

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9
Q

Pathology of BP

A

Linear IgG and C3 at DEJ, Ab to BP230 and Bp180 antigens at DEJ

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10
Q

Tx of BP

A

Topical steroids, systemic steroids, TCN/niacinamide, mycophenolate mofetil

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11
Q

Features of pemphigus vulgaris

A

Flaccid bullae, Nikolsky +, mucosal involvement

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12
Q

Pathology of PV

A

Ab against desmoglein 3 and 1, DIF reveals “chicken wire” pattern

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13
Q

Tx of PV

A

oral steroids, mycophenoalte mofetil, azathioprine, rituximab

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14
Q

Etiology of PV

A

Genetic, drug-induced, paraneoplastic

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15
Q

Features of pemphigus foliaceus

A

Superficial, scaly crust, “corn flakes”, no systemic symptoms

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16
Q

Pathology of PF

A

Ab against desmoglein 1

17
Q

Tx of PF

A

Steroids, mycophenolate mofetil, dapsone, antimalarials

18
Q

Features of IgA bullous dermatosis

A

Tense bullae in rosette or string of pearls; adult - drug induced (vanco), peds = chronic form

19
Q

Pathology of IgA bullous dermatosis

A

Subepidermal bulla with neutrophils, linear IgA at DEJ

20
Q

Features of dermatitis herpetiformis

A

Pruritic vesicles on extensor surfaces; associated with autoimmunity and sensitivity to gluten

21
Q

Pathology of DH

A

Subepidermal vesicles with neutrophils at DEF, DIF reveals granular IgA at dermal papillae

22
Q

Treatment of DH

A

Dapsone and gluten free diet

Dermatology Block (12 decks)

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