NSAIDs

Question 1

what drugs are Acytesalicylates?

Answer 1

Aspirin and Diflunisal

Question 2

What drugs are proprionic acid derivatives

Answer 2

Ibuprofen and naproxen

Question 3

What drugs are indole derivatives

Answer 3

Indomethacin

Question 4

what drugs are oxicams

Answer 4

piroxicam, meloxicam, tenoxicam

Question 5

COX-2 selective inhibitor

Answer 5

celecoxib

Question 6

What are the 6 groups of NSAIDs?

Answer 6

Acytesalicylates, proprionic acid derivatives, indole derivatives, oxicams, COX-2 selective inhibitor, Phenyl acetic acid derivatives

Question 7

What is the mechanism of action of Aspirin

Answer 7

inhibition of COX enzymes
low doses preferentially inhibits platelet COX1
high doses inhibit systemic COX 1 and COX2

Question 8

What is the mechanism of action of Ibuprofen? What is its unique use?

Answer 8

an NSAID that non-selectively inhibits COX1 and COX2

other uses: Close PDA

Question 9

what is the mechanism of action of Naproxen (aleve)

Answer 9

an NSAID that non-selectively inhibits COX1 and COX2

Question 10

what are the 3 things NSAIDs do?

Answer 10

Anti-pyretic (fever reducer), Anti-inflammatory, Analgesics (pain reducer)

Question 11

What is the mechanism of action of Indomethacin? what is it used for?

Answer 11

inhibits PGF2alpha- prevents uterin smooth muscle contraction, delays premature labor, more potent anti-inflammatory drug than aspirin
used to close PDA

Question 12

what are the side effects of Indomethacin? What are the contraindications?

Answer 12

GI and CNS

contraindications= GI disease

Question 13

What are the side effects of Aspirin (ASA)

Answer 13

GI upset

Question 14

Information for Piroxicam

Answer 14

NSAID
used for Osteoarthritis and Rheumatoid arthritis
strong analegic effects like opiods

Question 15

What is Meloxicam

Answer 15

an NSAID
COX2 selective inhibitor
used for RA and OA
less side effects than other NSAIDs

Question 16

What are the 3 phenyl acetyl acid derivatives? what types of conditions should they be used?

Answer 16

Ketorlax, tolmetin, Diclofenac

chronic long term inflammatory conditions

Question 17

what is the mechanism of action of Celecoxib?

Answer 17

COX2 selective inhibitor
NSAID
no GI side effects because no COX 1 inhibition at therapeutic level

Question 18

What 2 drugs are used to close PDA

Answer 18

Ibuprofen and Indomethacin are used with cardiac catherization

Question 19

What keeps PDA open?

Answer 19

PGE2 and PGI2

Question 20

What is a very rare condition the NSAIDs causes

Answer 20

SCARS
Steven Johnsons Syndrome- life threatening skin condition where epidermis and dermis separate
due to NSAID reaction

Question 21

What is associated with spontaneous aborption

Answer 21

non-aspirin NSAIDs

Question 22

Reyes Syndrome?

Answer 22

rare condition of <16 yo characterized by encephalopathy and steatosis that develops from a virus infection after the NSAID use- reason why only give kids acetominophen

Question 23

What are the toxicity signs of Aspirin

Answer 23

tinnitus, dehydration, fever, coma, metabolic acidosis, renal and respiratory failure

Question 24

Misoprostol?

Answer 24

PGE1
prevents NSAID induced gastric ulcers
labor induction for miscarriage

Question 25

Dinoprostone

Answer 25

PGE2

cervical ripening

Question 26

Dinoprost

Answer 26

PGF2alpha

labor induction

Question 27

Carboprost

Answer 27

PGF2alpha

labor induction, post partum hemorrhage

Question 28

Latanoprost

Answer 28

PGF2alpha

glaucoma

Question 29

Travoprost

Answer 29

PGF2alpha

glaucoma

Question 30

Epoprostenol

Answer 30

PGI2
vasodilator, inhibit platelet aggregation
used in pulmonary hypertension