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pharm exam 3 > CNS Stimulant And aDHd > Flashcards

CNS Stimulant And aDHd Flashcards

1
Q

What type of drugs should CNS stimulant avoid?

A

Any drugs that increase level of monoamines: avoid MAO I and SSR I agents

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2
Q

inhibit CNS suppressant and is a respiratory stimulant

A

Methylxanthine

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3
Q

which drug is used as the PRIMARY tx for apnea of prematurity

A

Caffeine

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4
Q

Theophylline

A

relaxes bronchial smooth muscle

Use COPD, asthma, apnea of prematurity

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5
Q

Psychomotor stimulant

A 
Amphetamine
Methamphetamine
Dexamephetamine
Methylphenidate
Cocaine
MDMA "ectasy"
Modafinil
Atoxmoxetine
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6
Q

Metabolism/excretion of CNS stimulants

A

Degraded by MAO-A and MAOB–>metabolized by liver–>active metabolites

Excreted in urine

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7
Q

how long is the duration of CNS Stimulant

A

SHORT duration, requires multiple dosing or extended release formula

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8
Q

inhibit GABA and glycine antagonists

A

Analeptic stimulants (doxapram)

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9
Q

which CNS stimulant cause enhancement of excitatory transmission–>increase catecholamine levels

A

Amphetamine, Cocaine

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10
Q

Which CNS stimulant enhance excitatory transmission by selective NE transporter BLOCKADE

A

Atoxmoxetine

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11
Q

ADHD tx

A

methylphenidate#1
Amphetamine
dextroamphetamine

Non stimulant:
Atomoxetine
Clonidine
Modafinil (not approved)
antidepressants
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12
Q

Drug-induced and postanesthesia respiratory depression tx

A

Doxapram

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13
Q

Performance enhancement

A

amphetamine, caffeine

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14
Q

Narcolpesy and sleep disorder tx

A

Modafinil**, amphetamine, dextroamphetamine, ephedrine, methphenidate

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15
Q

what drug is used as anorexiants for obesity?

A

amphetamine, dextroampehtamine

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16
Q

what is a major side effect to cocaine, other side effects?

A

severe weight loss

other:
CNS: euphoria, dysphoria, insonmia, irritability, tremor, headache, loss of aapetite

Cardio: MI, stroke

17
Q

what are some cardio side effects to cocaine

A

MI and stroke

18
Q

two types of symptoms for ADHD

A

inattention and impulsitivity/hyperactivity

19
Q

sympathomimetic effect

A

mydriasis, tachycardia, HTN

20
Q

what is amphetamine legally used for

A

narcolepsy, ADHD, short term weight loss

21
Q

Cocaine MOA

A

inhibits dopamine transporter to increase DA in synaptic cleft

22
Q

what part of the brain is affected with ADHD

A

dorsal lateral prefronal cotex lacks dopaine

23
Q

dextroamphetamine tx

A

ADHD, obesity, narcolepsy

24
Q

drug tx obesity? and MOA?

A

orlistat: lipase inhibitor. decrease GI fat absorption

pharm exam 3 (9 decks)

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