Lupus Flashcards
0
Q
Lupus Diagnosis
A
4 of 11 criteria: Malar rash Discoid lupus rash Photosensitivity Nephritis Oral/nasal ulcerations Nonerosive arthritis Cytopenia Pleuritis/pericarditis Encephalopathy
1
Q
Lupus Epidemiology
A
Onset >5yo, more common in teens
F:M 8:1
10-15% have +FH in 1st degree relative
Nephritis: 37% at diagnosis, 55% long-term
2
Q
Lupus Antibodies
A
Most sensitive: ANA
Most specific: dsDNA
Others: Ro/La, anti-Smith
*anti-Ro common in neonatal lupus
3
Q
Monitoring Lupus Activitiy
A
ANA, dsDNA
Complement levels
Urinary protein excretion if renal dz
*false + VDRL common
4
Q
Lupus Nephritis
A
Class I: normal Class II: mesangial proliferative Class III: focal proliferative Class IV: diffuse proliferative Class V: membranous
5
Q
Lupus Management
A
need renal bx to guide tx if nephritis
primarily steroids
Hydroxychloroquine helps rash, limits steroids
Sometimes azathioprine, cyclophosphamide
6
Q
Drug-Induced Lupus
A
Hydralazine Isoniazid PCN Sulfa AED's
7
Q
Neonatal Lupus
A
d/t maternal ab’s
transient
asx or cytopenia, malar rash, discoid lesions
can»_space; congenital 3rd degree heart block
