Flashcards in 28. Cases Deck (28):
What are the main sx of celiac disease?
Main extraintestinal manifestation?
FTT, fatigue, diarrhea, flatulence, weight loss
Diagnosis of celiac disease?
Anti-deaminated gliadin, tissue trans-glutaminase, endomysial IgA (also IgG for deam gliadin)
Celiac disease increases the risk for what malignancy?
T cell lymphoma
What HLA is associtated with celiac disease?
What marker identifies T cell specificity in celiac disease?
Definitive dx of celiac sprue must include:
1. Clinical documentation of malabsorption
2. Small bowel biopsy
3. Improvement in sx in and histology with GFD
What is the drug that is most commonly used for IBD?
Who more commonly gets crohn's disease?
Association with smoking
Caucasians and women
Smoking is a risk factor
What is the gross morphology of an intestine with Crohn disease?
Wall thickening and narrowed lumen
What are the microscopic features seen in Crohns
What are the main complications of Crohn's disease?
Protein losing enteropathy
Malabsoprtion and pernicious anemia
Increased risk for GI cancer
What are the extraintestinal manifestations of Crohn's
UC is limited to the colon with __% having backwash ileitis in severe pancolitis
Gross morphology of UC
Reg, granular, friable mucosa
Non-thickened wall **
Microscopic features of UC
Cryptitis and crypt abscesses
Inflammation limited to mucosa and submucosa
What are the main complications of UC?
Uncontrollable C. diff infection
What does inflammation in UC progress through to carcinoma?
What are the extraintestinal manifestations of UC?
Primary sclerosing cholangitis **
Does Crohn's or UC have skip lesions?
Does Crohn's or UC have the potential for toxic megacolon?
Does Crohn's or UC have the potential for perianal fistula?
Does Crohn's or UC have the potential for fat/vitamin malabsorption?
Does Crohn's or UC have recurrence after surgery?
Does Crohn's or UC have inflammation limited to the mucosa?
Does Crohn's or UC have wall thickening?
Does Crohn's or UC have strictures?
What is a pseudomembrane?
Plaque-like adhesion of fibrinopurulent necrotic debris overlying sites of mucosal injury