Week 7 PBL Antineoplastic drugs

Question 1

cytotoxic

Answer 1

kills rapidly dividing cells

Question 2

cyclophosphamide

Answer 2

• alkylates guanine, creates crosslinking, prevents DNA replication, activates p53, leading to cell death
• not cell cycle specific

Question 3

Doxorubicin/Epirubicin (anthracycline antibiotics)

Answer 3

• intercelates, DNA breakages and other cytotoxic actions, activates p53, cell death
• will cause death even in cancers with p53 mutations (necrosis instead of apoptosis)
• not cell cycle specific

Question 4

5- FU

Answer 4

inhibits TS, decreased DNA syntehsis, cell death

-S phase specific

Question 5

Common Side effects of cancer drugs

Answer 5

*cancer drugs target rapidly dividing cells
Hair follicle cells - hair loss
immune cell progenitors- suppressed immune system
Embryonic- fetal defects
Epithelial intestinal cells - nausea, vomiting, and diarrhea

Question 6

Paclitaxel

Answer 6

• stabilizes microtubules, prevents organized breakdown of mitotic spindle, stuck in metaphase
• M phase specific

Question 7

What is the major dose-limiting toxicity of cytotoxic drug

Answer 7

BONE MARROW SUPPRESSION, need to administer drugs in cycles to allow for repopulation of immune cels