Viral Hepatitis

Question 1

Which two hep viruses are self limited?

Answer 1

HepA and E

Question 2

Which Hep viruses have chronic hep?

Answer 2

Hep B, C, and D

Question 3

Diagnostic serology for PBC?

Answer 3

Small bile ducts

Anti-mitochondrial antibody

Question 4

Bile system characteristic for PSC?

PSC Correlated to what condition?

Answer 4

• Large bile ducts - BEADED

- IBD = usually also have PSC

Question 5

HepA -family of virus?

Answer 5

picornaviridae

Question 6

Food or water contaminated with HepA?

Answer 6

• food handlers
• raw shelfish
• travel to endemic areas

Question 7

HepB virus - classification/family?

Answer 7

hepadnaviridae

Question 8

Only hep virus that has DNA genome?

Answer 8

HepB

Question 9

Most common race with HepB?

Answer 9

ASIANS!

THEN AFRICANS!

Question 10

Treat HepB in an adult?

Answer 10

Nothing - observe for first 6mo bc 80% chance he/she will fight it off on their own w/out chronic disease

Question 11

HBV chances of developing chronic hepatitis?

Answer 11

The younger you are the more risk. as you get older less risk

Question 12

Immune tolerance and HepB

-What is it?

Answer 12

-seen in babies who get HepB - their immune system isnt ready to mount an attack yet so the virus runs rampant. Immune system not going yet means no destruction of HepB infected hepatocytes = no hepatitis

Question 13

Only curative treatment for HepB?

Answer 13

Interferon! - cannot use in patients with cirrhosis

-the pills only stop continued liver damage but lifelong treatment

Question 14

Why dont we use lamivudine anymore?

Answer 14

Resistance eventually brings back damage

Question 15

Benefit to adofovir?

Answer 15

effective against lamivudine-resistant mutants

Question 16

HepD

• what class/family?
• how does it inftect?

Answer 16

• delta

- needs HepB to replicate

Question 17

Special thing about HepE?

Answer 17

causes fulminant hep failure in pregnant women

in other people wokrs just like HepA!

Question 18

HepC virus family?

Answer 18

flavivirus

Question 19

Interesting effect of HepC on the liver?

Answer 19

The liver enzymes can go up at certain times or down. So just because you check liver enzymes one day and they are low does not mean that they dont have the virus

Question 20

HepC and ALT relationship:

Answer 20

No correlation! Can go up or down or be normal at times!

Question 21

HepC and alcohol relationship:

Answer 21

Alcohol causes disease to progress MUCH FASTER!

Question 22

End point of sustained virological response:

Answer 22

cant get rid of it but down to levels where it cant divide and do damage

not a cure

Question 23

WHy pegilate the drug interferon?

Answer 23

basically adding a huge protein onto the drug = longer drug life

Question 24

Best new medication for HepC

Answer 24

Harvoni!